RETN resistin [Homo sapiens (human)] - Gene

Summary

Official Symbol: RETNprovided by HGNC
Official Full Name: resistinprovided by HGNC
Primary source: HGNC:HGNC:20389
See related: Ensembl:ENSG00000104918 MIM:605565; AllianceGenome:HGNC:20389
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADSF; RENT; RSTN; XCP1; FIZZ3; RETN1
Summary: This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020]
Expression: Biased expression in bone marrow (RPKM 57.7) and lung (RPKM 6.4) See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (7669049..7670455)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (7669929..7671334)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (7733935..7735341)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serum resistin and lipid profile in primigravida females with and without preeclampsia: An analytical cross-sectional study.
Title: Serum resistin and lipid profile in primigravida females with and without preeclampsia: An analytical cross-sectional study.
Resistin Pathway as Novel Mechanism of Post-lung Transplantation Bronchial Stenosis.
Title: Resistin Pathway as Novel Mechanism of Post-lung Transplantation Bronchial Stenosis.
Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.
Title: Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes.
Study on the correlation between gene polymorphisms of adiponectin and resistin levels and abdominal aortic aneurysm.
Title: Study on the correlation between gene polymorphisms of adiponectin and resistin levels and abdominal aortic aneurysm.
Relationship of circulating resistin levels with muscle mass determined by bioelectrical impedance in females with obesity.
Title: Relationship of circulating resistin levels with muscle mass determined by bioelectrical impedance in females with obesity.
The differential role of resistin on invasive liver cancer cells.
Title: The differential role of resistin on invasive liver cancer cells.
Impacts of RETN genetic polymorphism on breast cancer development in Beni-Suef females, Egypt.
Title: Impacts of RETN genetic polymorphism on breast cancer development in Beni-Suef females, Egypt.
Association of adipocytokines and adipocytokine ratios with cardiovascular risk factors in Japanese preadolescents.
Title: Association of adipocytokines and adipocytokine ratios with cardiovascular risk factors in Japanese preadolescents.
Relation of resistin gene variants to resistin plasma levels and altered susceptibility to polycystic ovary syndrome: A case control study.
Title: Relation of resistin gene variants to resistin plasma levels and altered susceptibility to polycystic ovary syndrome: A case control study.
Relationship of resistin gene polymorphism (rs7139228) with resistin levels and metabolic syndrome risk in obese subjects.
Title: Relationship of resistin gene polymorphism (rs7139228) with resistin levels and metabolic syndrome risk in obese subjects.

Submit: New GeneRIF Correction See all GeneRIFs (596)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Type 2 diabetes mellitus MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder	Compare labs

EBI GWAS Catalog

Description
Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of resistin (RETN) in peptide-treated PBMCs	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483335

NoName (e-PCR)
- UniSTS:480729

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of progesterone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in specific granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: resistin

Names: C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; adipose tissue-specific secretory factor; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; cysteine-rich secreted protein A12-alpha-like 2; cysteine-rich secreted protein FIZZ3; found in inflammatory zone 3; resistin delta2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023447.1 RefSeqGene

Range

4964..6370

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001193374.2 → NP_001180303.1 resistin isoform a precursor

See identical proteins and their annotated locations for NP_001180303.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AC008763, AY207314

Consensus CDS

CCDS12182.1

UniProtKB/Swiss-Prot

D6W649, Q540D9, Q76B53, Q9HD89

Conserved Domains (1) summary

pfam06954
Location:22 → 106

Resistin
NM_001385725.1 → NP_001372654.1 resistin isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.

Source sequence(s)

AC008763

Consensus CDS

CCDS12182.1

UniProtKB/Swiss-Prot

D6W649, Q540D9, Q76B53, Q9HD89

Conserved Domains (1) summary

pfam06954
Location:22 → 106

Resistin
NM_001385726.1 → NP_001372655.1 resistin isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (b).

Source sequence(s)

AC008763

Conserved Domains (1) summary

pfam06954
Location:22 → 120

Resistin
NM_001385727.1 → NP_001372656.1 resistin isoform c precursor

Status: REVIEWED

Source sequence(s)

AC008763

Consensus CDS

CCDS92503.1

Related

ENSP00000485998.1, ENST00000629642.1

Conserved Domains (1) summary

cl06143
Location:22 → 80

RELM; resistin-like molecule (RELM) hormone family
NM_020415.4 → NP_065148.1 resistin isoform a precursor

See identical proteins and their annotated locations for NP_065148.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a. Variants 1-3 all encode the same isoform (a).

Source sequence(s)

AC008763, AF205952, BC069302

Consensus CDS

CCDS12182.1

UniProtKB/Swiss-Prot

D6W649, Q540D9, Q76B53, Q9HD89

Related

ENSP00000221515.1, ENST00000221515.6

Conserved Domains (1) summary

pfam06954
Location:22 → 106

Resistin