U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gmppa GDP-mannose pyrophosphorylase A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36730, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gmppaprovided by FlyBase
    Official Full Name
    GDP-mannose pyrophosphorylase Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034035
    Locus tag
    Dmel_CG8207
    See related
    AllianceGenome:FB:FBgn0034035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8207; Dmel\CG8207
    Summary
    Predicted to enable nucleotidyltransferase activity. Predicted to be involved in biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm; extended germ band embryo; and gut section. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gmppa in Genome Data Viewer
    Location:
    52B5-52B5; 2-75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15677218..15678956, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11564723..11566461, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-278 stem loop Neighboring gene fusilli Neighboring gene antisense RNA:CR45143 Neighboring gene Vacuolar H[+] ATPase 14kD subunit 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning. Wakabayashi-Ito N, et al. Dev Biol, 2001 Jan 1. PMID 11133153
    2. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article
    3. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article
    4. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    GDP-mannose pyrophosphorylase A
    Names
    CG8207-PA
    Gmppa-PA
    NP_611051.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15677218..15678956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137207.4 → NP_611051.2  GDP-mannose pyrophosphorylase A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611051.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXU3, Q9V7E1
      Related
      FBpp0086475
      Conserved Domains (3) summary
      cd06428
      Location:4 → 270
      M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase
      COG1208
      Location:1 → 366
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
      cl00160
      Location:306 → 372
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXU3 Q8SXU3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous