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    Cuta cutA divalent cation tolerance homolog [ Mus musculus (house mouse) ]

    Gene ID: 67675, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cutaprovided by MGI
    Official Full Name
    cutA divalent cation tolerance homologprovided by MGI
    Primary source
    MGI:MGI:1914925
    See related
    Ensembl:ENSMUSG00000024194 AllianceGenome:MGI:1914925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610039D01Rik; 1810022E02Rik; 1810060C03Rik; 2700094G22Rik
    Summary
    Predicted to enable copper ion binding activity and enzyme binding activity. Predicted to be involved in protein localization. Predicted to be located in membrane. Orthologous to human CUTA (cutA divalent cation tolerance homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 82.5), duodenum adult (RPKM 48.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 13.6 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27156946..27158847, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26937972..26939884, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C5B Neighboring gene microRNA 6967-1 Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene PHD finger protein 1 Neighboring gene microRNA 6968 Neighboring gene synaptic Ras GTPase activating protein 1 homolog (rat) Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unusual transfer of CutA into the secretory pathway, evidenced by fusion proteins with acetylcholinesterase. Liang D, et al. FEBS J, 2009 Aug. PMID 19645739
    2. Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Hou P, et al. Neurobiol Aging, 2015 Mar. PMID 25557959
    3. Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase. Liang D, et al. J Biol Chem, 2009 Feb 20. PMID 19049969
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an N-terminal CutA domain actually drives AChE into the endoplasmic reticulum and allows its secretion
      Title: Unusual transfer of CutA into the secretory pathway, evidenced by fusion proteins with acetylcholinesterase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to metal ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein CutA
    Names
    brain acetylcholinesterase putative membrane anchor
    divalent cation tolerant protein CUTA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026307.3 → NP_080583.3  protein CutA isoform 1 precursor

      See identical proteins and their annotated locations for NP_080583.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA197830, AK002828, CA323205
      Consensus CDS
      CCDS28557.1
      UniProtKB/Swiss-Prot
      Q3TXB6, Q8CI44, Q9CQ89, Q9D1L4
      Related
      ENSMUSP00000025027.9, ENSMUST00000025027.10
      Conserved Domains (1) summary
      pfam03091
      Location:70 → 164
      CutA1; CutA1 divalent ion tolerance protein

    2. NM_026948.3 → NP_081224.1  protein CutA isoform 2

      See identical proteins and their annotated locations for NP_081224.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA197830, AK003381, CA323205
      Consensus CDS
      CCDS37519.1
      UniProtKB/TrEMBL
      D5MCW4
      Related
      ENSMUSP00000110585.2, ENSMUST00000114935.9
      Conserved Domains (1) summary
      pfam03091
      Location:47 → 141
      CutA1; CutA1 divalent ion tolerance protein

    RNA

    1. NR_104458.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a splice junction in the 5' region and has an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK007912, BY033979, BY057392, CK624897
      Related
      ENSMUST00000236888.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27156946..27158847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250013.2 → XP_030105873.1  protein CutA isoform X1

      Conserved Domains (1) summary
      pfam03091
      Location:167 → 226
      CutA1; CutA1 divalent ion tolerance protein

    2. XM_006524832.5 → XP_006524895.1  protein CutA isoform X2

      UniProtKB/TrEMBL
      A0A494BAZ9
      Conserved Domains (1) summary
      pfam03091
      Location:69 → 104
      CutA1; CutA1 divalent ion tolerance protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ89.3 GenPept UniProtKB/Swiss-Prot:Q9CQ89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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