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    Ubxn11 UBX domain protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 67586, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ubxn11provided by MGI
    Official Full Name
    UBX domain protein 11provided by MGI
    Primary source
    MGI:MGI:1914836
    See related
    Ensembl:ENSMUSG00000012126 AllianceGenome:MGI:1914836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Soc; Soci; Ubxd5; D4Bwg1540e; 4930506L07Rik
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and cytoskeleton. Orthologous to human UBXN11 (UBX domain protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 53.9), thymus adult (RPKM 6.2) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.3; 4 66.5 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133829811..133854095)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134102500..134126784)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1658 Neighboring gene STARR-positive B cell enhancer ABC_E9600 Neighboring gene STARR-positive B cell enhancer ABC_E842 Neighboring gene STARR-positive B cell enhancer ABC_E4678 Neighboring gene STARR-positive B cell enhancer ABC_E10264 Neighboring gene CD52 antigen Neighboring gene STARR-seq mESC enhancer starr_11667 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133677585-133677803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133680177-133680360 Neighboring gene SH3 domain binding glutamic acid-rich protein-like 3 Neighboring gene centrosomal protein 85 Neighboring gene STARR-positive B cell enhancer mm9_chr4:133715471-133715771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133742713-133742822 Neighboring gene STARR-positive B cell enhancer ABC_E843

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Katoh H, et al. Mol Cell Biol, 2002 May. PMID 11940653, Free PMC Article
    2. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. Aksu S, et al. J Appl Genet, 2007. PMID 17495347
    3. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UBX domain-containing protein 11
    Names
    UBX domain containing 5
    UBX domain-containing protein 5
    socius

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026257.3 → NP_080533.1  UBX domain-containing protein 11

      See identical proteins and their annotated locations for NP_080533.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
      Source sequence(s)
      AK048494, AL670680
      Consensus CDS
      CCDS18763.1
      UniProtKB/Swiss-Prot
      Q8C843, Q8VCP5, Q9CWP0, Q9D572
      Related
      ENSMUSP00000074255.5, ENSMUST00000074690.11
      Conserved Domains (3) summary
      pfam08059
      Location:232 → 302
      SEP; SEP domain
      cl00155
      Location:394 → 461
      UBQ; Ubiquitin-like proteins
      cl21454
      Location:172 → 225
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_045571.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is thought not to be protein-coding.
      Source sequence(s)
      AK048494, AL670680
      Related
      ENSMUST00000156323.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133829811..133854095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539124.4 → XP_006539187.1  UBX domain-containing protein 11 isoform X3

      UniProtKB/TrEMBL
      I7HIQ5
      Related
      ENSMUSP00000064030.3, ENSMUST00000070246.9
      Conserved Domains (2) summary
      cd17077
      Location:314 → 383
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:153 → 224
      SEP; SEP domain

    2. XM_006539127.4 → XP_006539190.1  UBX domain-containing protein 11 isoform X5

      Conserved Domains (1) summary
      cl02662
      Location:271 → 294
      SEP; SEP domain

    3. XM_006539122.3 → XP_006539185.1  UBX domain-containing protein 11 isoform X2

      See identical proteins and their annotated locations for XP_006539185.1

      Conserved Domains (2) summary
      cd17077
      Location:320 → 389
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:159 → 230
      SEP; SEP domain

    4. XM_030253726.2 → XP_030109586.1  UBX domain-containing protein 11 isoform X4

      UniProtKB/TrEMBL
      I7HIQ5
      Conserved Domains (2) summary
      cd17077
      Location:237 → 306
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:76 → 147
      SEP; SEP domain

    5. XM_006539123.4 → XP_006539186.1  UBX domain-containing protein 11 isoform X2

      See identical proteins and their annotated locations for XP_006539186.1

      Conserved Domains (2) summary
      cd17077
      Location:320 → 389
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:159 → 230
      SEP; SEP domain

    6. XM_011250325.4 → XP_011248627.1  UBX domain-containing protein 11 isoform X1

      Conserved Domains (2) summary
      cd17077
      Location:363 → 432
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:202 → 273
      SEP; SEP domain

    7. XM_011250326.4 → XP_011248628.1  UBX domain-containing protein 11 isoform X2

      See identical proteins and their annotated locations for XP_011248628.1

      Conserved Domains (2) summary
      cd17077
      Location:320 → 389
      UBX_UBXN11; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 11 (UBXN11) and similar proteins
      pfam08059
      Location:159 → 230
      SEP; SEP domain

    RNA

    1. XR_390778.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D572.1 GenPept UniProtKB/Swiss-Prot:Q9D572

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