Pa2g4 proliferation-associated 2G4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pa2g4provided by MGI
Official Full Name: proliferation-associated 2G4provided by MGI
Primary source: MGI:MGI:894684
See related: Ensembl:ENSMUSG00000025364 AllianceGenome:MGI:894684
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ebp1; 38kDa; Plfap
Summary: Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of ribonucleoprotein complex. Is expressed in brain; heart; limb; and lung mesenchyme. Orthologous to human PA2G4 (proliferation-associated 2G4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14 (RPKM 85.0), CNS E11.5 (RPKM 68.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.09 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128393635..128401803, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128557766..128565934, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
Title: PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.
Title: Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.
Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
Title: Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
ErbB3-binding protein 1 (EBP1) is implicated in diverse cellular functions, including apoptosis, cell proliferation, and differentiation. Essential role for EBP1 in embryonic development and implicate its function in transcriptional regulation.
Title: Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control.
identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1
Title: ERBB3-Binding Protein 1 (EBP1) Is a Novel Developmental Pluripotency-Associated-4 (DPPA4) Cofactor in Human Pluripotent Cells.
results show that EBP1 interacts directly with PPIns and associate with PtdIns(3,4,5)P3 in the nucleolus.
Title: A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction.
Ebp1 p42 isoform regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.
Title: P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP.
EBP1 is a novel component of the ZFP809-TRIM28 silencing complex to restrict the moloney murine leukemia virus replication in embryonic cells.
Title: EBP1, a novel host factor involved in primer binding site-dependent restriction of moloney murine leukemia virus in embryonic cells.
Ebp1 has a role in the regulation of embryonic muscle progenitors and adult muscle stem cells, which likely operates independently of ErbB3 signaling
Title: ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells.
IGF-1 production and IGBP-3 and 4 protein levels were reduced in both embryo fibroblasts and adult knock-out mice. The proliferation of fibroblasts derived from Day 12.5 knock out embryos was also decreased as compared to that of wild type cells.
Title: Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125599 (e-PCR)
- UniSTS:162413

RH129661 (e-PCR)
- UniSTS:212958

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info	PubMed
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: proliferation-associated protein 2G4

Names: ErbB3-binding protein 1; IRES-specific cellular trans-acting factor 45 kDa; ITAF45; mpp1; proliferation-associated 2G4, 38kD; proliferation-associated protein 1; protein p38-2G4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.