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    Arel1 apoptosis resistant E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 68497, updated on 2-May-2024

    Summary

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    Official Symbol
    Arel1provided by MGI
    Official Full Name
    apoptosis resistant E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:1915747
    See related
    Ensembl:ENSMUSG00000042350 AllianceGenome:MGI:1915747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110018G07Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in protein ubiquitination; regulation of inflammatory response; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.2), CNS E18 (RPKM 18.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 39.46 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84964914..85017674, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84918140..84970878, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_32756 Neighboring gene STARR-seq mESC enhancer starr_32757 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KIAA0317 regulates pulmonary inflammation through SOCS2 degradation. Lear TB, et al. JCI Insight, 2019 Oct 3. PMID 31578312, Free PMC Article
    2. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. Lear T, et al. J Exp Med, 2016 May 30. PMID 27162139, Free PMC Article
    3. Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS. Kim JB, et al. J Biol Chem, 2013 Apr 26. PMID 23479728, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Chemically induced (ENU) (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • Kiaa0317, mKIAA0317

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K33-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-resistant E3 ubiquitin protein ligase 1
    Names
    apoptosis-resistant HECT-type E3 ubiquitin transferase 1
    NP_001351118.1
    NP_001351119.1
    NP_835166.3
    XP_006516254.1
    XP_030102751.1
    XP_030102752.1
    XP_036013493.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364189.1 → NP_001351118.1  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      CR974585
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464 → 821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    2. NM_001364190.1 → NP_001351119.1  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      AK077015, AK147491, CR974585
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464 → 821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    3. NM_178065.5 → NP_835166.3  apoptosis-resistant E3 ubiquitin protein ligase 1

      Status: VALIDATED

      Source sequence(s)
      AW045956, BC060658, BC079590, CJ128427
      Consensus CDS
      CCDS26051.1
      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Related
      ENSMUSP00000048780.8, ENSMUST00000043169.14
      Conserved Domains (2) summary
      cd00078
      Location:464 → 821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    RNA

    1. NR_157097.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CR974585
      Related
      ENSMUST00000163231.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84964914..85017674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516191.5 → XP_006516254.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:454 → 811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 143
      Filamin; Filamin/ABP280 repeat

    2. XM_030246892.2 → XP_030102752.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2

      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:454 → 811
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 143
      Filamin; Filamin/ABP280 repeat

    3. XM_036157600.1 → XP_036013493.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464 → 821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    4. XM_030246891.1 → XP_030102751.1  apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6P9Q1, Q80YC4, Q8C5W5, Q8CHG5
      UniProtKB/TrEMBL
      Q3U3Y1
      Conserved Domains (2) summary
      cd00078
      Location:464 → 821
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:56 → 154
      Filamin; Filamin/ABP280 repeat

    RNA

    1. XR_872717.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHG5.2 GenPept UniProtKB/Swiss-Prot:Q8CHG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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