Akip1 A-kinase interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akip1provided by RGD
Official Full Name: A-kinase interacting protein 1provided by RGD
Primary source: RGD:1306959
See related: Ensembl:ENSRNOG00000013744 AllianceGenome:RGD:1306959
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306959
Summary: Predicted to be involved in regulation of NIK/NF-kappaB signaling. Predicted to act upstream of or within substrate adhesion-dependent cell spreading. Predicted to be active in nucleoplasm. Orthologous to human AKIP1 (A-kinase interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 64.0), Lung (RPKM 49.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (173169520..173178445)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (163734730..163743648)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (174330628..174339494)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-320 plays an important role in regulating cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1 and inducing the mitochondrial apoptotic pathway.
Title: MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
AKIP1 expression modulates mitochondrial function in rat neonatal cardiomyocytes.
Title: AKIP1 expression modulates mitochondrial function in rat neonatal cardiomyocytes.
our results show that AKIP1 is induced in hypertrophic hearts and can stimulate adaptive cardiomyocyte growth, which involves Akt signaling
Title: AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway.
Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart.
Title: A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.

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General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase-interacting protein 1

Names: A kinase (PRKA) interacting protein 1; proline-rich protein BCA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.