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    Slc35c2 solute carrier family 35 member C2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311637, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Slc35c2provided by RGD
    Official Full Name
    solute carrier family 35 member C2provided by RGD
    Primary source
    RGD:1311250
    See related
    Ensembl:ENSRNOG00000018649 AllianceGenome:RGD:1311250
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable antiporter activity. Predicted to be involved in UDP-glucose transmembrane transport. Predicted to act upstream of or within negative regulation of gene expression; positive regulation of Notch signaling pathway; and protein O-linked fucosylation. Located in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human SLC35C2 (solute carrier family 35 member C2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 44.5), Kidney (RPKM 42.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc35c2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174431688..174442852, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154012262..154023549, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161801194..161812318, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486205 Neighboring gene uncharacterized LOC134486204 Neighboring gene engulfment and cell motility 2 Neighboring gene zinc finger protein 663 Neighboring gene zinc finger protein 334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. Lu L, et al. J Biol Chem, 2010 Nov 12. PMID 20837470, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein O-linked fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 35 member C2
    Names
    solute carrier family 35 (GDP-fucose transporter), member C2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107803.1 → NP_001101273.1  solute carrier family 35 member C2

      See identical proteins and their annotated locations for NP_001101273.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474005
      UniProtKB/TrEMBL
      A0A0G2K491, B2RYM9, F7ELK2
      Conserved Domains (1) summary
      pfam03151
      Location:16 → 313
      TPT; Triose-phosphate Transporter family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      174431688..174442852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283880.1 → XP_063139950.1  solute carrier family 35 member C2 isoform X3

    2. XM_063283872.1 → XP_063139942.1  solute carrier family 35 member C2 isoform X1

    3. XM_063283876.1 → XP_063139946.1  solute carrier family 35 member C2 isoform X1

    4. XM_006235588.5 → XP_006235650.1  solute carrier family 35 member C2 isoform X2

      See identical proteins and their annotated locations for XP_006235650.1

      UniProtKB/TrEMBL
      A0A0G2K491, B2RYM9, F7ELK2
      Related
      ENSRNOP00000025238.4
      Conserved Domains (1) summary
      pfam03151
      Location:16 → 313
      TPT; Triose-phosphate Transporter family

    5. XM_063283878.1 → XP_063139948.1  solute carrier family 35 member C2 isoform X2

      UniProtKB/TrEMBL
      B2RYM9, F7ELK2

    6. XM_063283873.1 → XP_063139943.1  solute carrier family 35 member C2 isoform X1

    7. XM_008762504.4 → XP_008760726.1  solute carrier family 35 member C2 isoform X2

      See identical proteins and their annotated locations for XP_008760726.1

      UniProtKB/TrEMBL
      A0A0G2K491, B2RYM9, F7ELK2
      Conserved Domains (1) summary
      pfam03151
      Location:16 → 313
      TPT; Triose-phosphate Transporter family

    8. XM_063283879.1 → XP_063139949.1  solute carrier family 35 member C2 isoform X2

      UniProtKB/TrEMBL
      B2RYM9, F7ELK2

    9. XM_063283874.1 → XP_063139944.1  solute carrier family 35 member C2 isoform X1

    10. XM_063283877.1 → XP_063139947.1  solute carrier family 35 member C2 isoform X2

      UniProtKB/TrEMBL
      B2RYM9, F7ELK2

    11. XM_063283875.1 → XP_063139945.1  solute carrier family 35 member C2 isoform X1

    12. XM_017591795.3 → XP_017447284.1  solute carrier family 35 member C2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K491, B2RYM9, F7ELK2
    Nucleotide Protein Strain
    Heading Accession and Version

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