Scaf1 SR-related CTD-associated factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scaf1provided by RGD
Official Full Name: SR-related CTD-associated factor 1provided by RGD
Primary source: RGD:708405
See related: Ensembl:ENSRNOG00000056946 AllianceGenome:RGD:708405
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sr-a1
Summary: Enables protein domain specific binding activity. Involved in mRNA processing and transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human SCAF1 (SR-related CTD associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 56.5), Kidney (RPKM 46.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104621927..104635161, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95485448..95499389, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100997724..101010855, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128036 (e-PCR)
- UniSTS:211344

AI480556 (e-PCR)
- UniSTS:159638

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II C-terminal domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II C-terminal domain binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: splicing factor, arginine/serine-rich 19

Names: CTD-binding SR-like protein rA1; CTD-binding SR-like rA1; SR-related and CTD-associated factor 1; serine arginine-rich pre-mRNA splicing factor SR-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001400823.1 → NP_001387752.1 splicing factor, arginine/serine-rich 19

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63624
NM_001414200.1 → NP_001401129.1 splicing factor, arginine/serine-rich 19

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63624
NM_019384.2 → NP_062257.2 splicing factor, arginine/serine-rich 19

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q63624

Related

ENSRNOP00000072566.1, ENSRNOT00000081430.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104621927..104635161 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272028.1 → XP_063128098.1 splicing factor, arginine/serine-rich 19 isoform X2
XM_039088703.2 → XP_038944631.2 splicing factor, arginine/serine-rich 19 isoform X1

UniProtKB/TrEMBL

A6JAV6