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    Klc1 kinesin light chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171041, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klc1provided by RGD
    Official Full Name
    kinesin light chain 1provided by RGD
    Primary source
    RGD:621411
    See related
    Ensembl:ENSRNOG00000011572 AllianceGenome:RGD:621411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kns2
    Summary
    Enables tubulin binding activity. Involved in intracellular protein transport and protein localization to synapse. Located in several cellular components, including growth cone; neuronal cell body; and vesicle. Part of kinesin complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and relapsing-remitting multiple sclerosis. Orthologous to human KLC1 (kinesin light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 438.1), Muscle (RPKM 135.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (136644592..136690399)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (130823416..130866729)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (136330151..136373716)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene BAG cochaperone 5 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene uncharacterized LOC134479261 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene UPF0235 protein C15orf40 homolog Neighboring gene atherin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease. Traina G, et al. Neurochem Int, 2008 Dec. PMID 18761385
    2. Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin. Ward BM, et al. J Virol, 2004 Mar. PMID 14963148, Free PMC Article
    3. Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing. Cyr JL, et al. Proc Natl Acad Sci U S A, 1991 Nov 15. PMID 1946431, Free PMC Article
    4. Kinesin light chain 1 gene haplotypes in three conformational diseases. von Otter M, et al. Neuromolecular Med, 2010 Sep. PMID 19911314
    5. Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Konishi Y, et al. Nat Neurosci, 2009 May. PMID 19377471

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Consistently, inhibition of tubulin tyrosination in rat hippocampal neurons resulted in the distribution of truncated kinesin-1 in both axons and dendrites.
      Title: Tubulin tyrosination navigates the kinesin-1 motor domain to axons.
    2. We observed that acetyl-l-carnitine increases the light-chain subunit of kinesin-1 gene expression.The fast anterograde axonal transport of amyloid-beta peptide is mediated by direct binding to the light-chain subunit of kinesin-1.
      Title: Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease.
    3. For Kinesin-1, activation requires a global conformational change that separates the kinesin heavy chain (KHC) motor and tail domains and a local conformational change that moves the KHC motor domains closer together.
      Title: Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells.
    4. Binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for microtubule binding and motility.
      Title: Two binding partners cooperate to activate the molecular motor Kinesin-1.
    5. Kidins220/ARMS-positive carriers undergo a kinesin-1-dependent transport linked to neurotrophin action.
      Title: Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation.
    6. the intermediate chain of dynein binds to kinesin light chains 1 and 2. The interaction is both direct and specific
      Title: A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.
    7. Calsyntenin-1 links a certain type of vesicular and tubulovesicular organelles to the Kinesin-1 motor.
      Title: Calsyntenin-1 docks vesicular cargo to kinesin-1.
    8. Together, these results indicate that DISC1 regulates the localization of NUDEL/LIS1/14-3-3epsilon complex into the axons as a cargo receptor for axon elongation.
      Title: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.
    9. wild-type torsinA undergoes anterograde transport along microtubules mediated by kinesin and may act as a molecular chaperone regulating kinesin activity and/or cargo binding
      Title: The early onset dystonia protein torsinA interacts with kinesin light chain 1.
    10. These results indicate that the CRMP-2/Kinesin-1 complex regulates soluble tubulin transport to the distal part of the growing axon.
      Title: Tubulin and CRMP-2 complex is transported via Kinesin-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axo-dendritic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress granule disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary rootlet ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin light chain 1
    Names
    KLC 1
    kinesin 2
    NP_001075441.1
    NP_001075442.1
    NP_001075443.1
    XP_006240683.1
    XP_006240684.1
    XP_006240685.1
    XP_006240689.1
    XP_006240690.1
    XP_006240691.1
    XP_006240692.1
    XP_038967663.1
    XP_038967665.1
    XP_038967667.1
    XP_038967668.1
    XP_038967669.1
    XP_063117578.1
    XP_063117579.1
    XP_063117580.1
    XP_063117581.1
    XP_063117582.1
    XP_063117583.1
    XP_063117584.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081972.1 → NP_001075441.1  kinesin light chain 1 isoform A

      Status: PROVISIONAL

      Source sequence(s)
      M75146
      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:296 → 337
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:293 → 370
      TPR_12; Tetratricopeptide repeat

    2. NM_001081973.1 → NP_001075442.1  kinesin light chain 1 isoform B

      Status: PROVISIONAL

      Source sequence(s)
      M75147
      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    3. NM_001081974.1 → NP_001075443.1  kinesin light chain 1 isoform C

      See identical proteins and their annotated locations for NP_001075443.1

      Status: PROVISIONAL

      Source sequence(s)
      M75148
      UniProtKB/Swiss-Prot
      P37285
      UniProtKB/TrEMBL
      A0A8L2RC24
      Related
      ENSRNOP00000075931.1, ENSRNOT00000092774.2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      136644592..136690399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261508.1 → XP_063117578.1  kinesin light chain 1 isoform X1

    2. XM_063261512.1 → XP_063117582.1  kinesin light chain 1 isoform X9

    3. XM_063261510.1 → XP_063117580.1  kinesin light chain 1 isoform X4

    4. XM_063261513.1 → XP_063117583.1  kinesin light chain 1 isoform X11

    5. XM_063261509.1 → XP_063117579.1  kinesin light chain 1 isoform X3

    6. XM_063261511.1 → XP_063117581.1  kinesin light chain 1 isoform X7

    7. XM_006240621.5 → XP_006240683.1  kinesin light chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:296 → 337
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:293 → 370
      TPR_12; Tetratricopeptide repeat

    8. XM_006240623.5 → XP_006240685.1  kinesin light chain 1 isoform X6

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:296 → 337
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:293 → 370
      TPR_12; Tetratricopeptide repeat

    9. XM_006240627.5 → XP_006240689.1  kinesin light chain 1 isoform X11

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    10. XM_006240622.5 → XP_006240684.1  kinesin light chain 1 isoform X5

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13374
      Location:296 → 337
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:293 → 370
      TPR_12; Tetratricopeptide repeat

    11. XM_039111735.2 → XP_038967663.1  kinesin light chain 1 isoform X8

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    12. XM_039111740.2 → XP_038967668.1  kinesin light chain 1 isoform X15

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    13. XM_039111737.2 → XP_038967665.1  kinesin light chain 1 isoform X10

      UniProtKB/Swiss-Prot
      P37285
      UniProtKB/TrEMBL
      A0A8L2RC24
      Related
      ENSRNOP00000076048.2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    14. XM_039111739.2 → XP_038967667.1  kinesin light chain 1 isoform X14

      UniProtKB/TrEMBL
      A0A8L2RC24
      Related
      ENSRNOP00000015935.8
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    15. XM_006240629.5 → XP_006240691.1  kinesin light chain 1 isoform X13

      UniProtKB/TrEMBL
      A0A8L2QTG3, A0A8L2RC24
      Related
      ENSRNOP00000060469.4
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    16. XM_006240628.5 → XP_006240690.1  kinesin light chain 1 isoform X12

      UniProtKB/TrEMBL
      A0A140TAB3, A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    17. XM_063261514.1 → XP_063117584.1  kinesin light chain 1 isoform X17

    18. XM_006240630.5 → XP_006240692.1  kinesin light chain 1 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    19. XM_039111741.2 → XP_038967669.1  kinesin light chain 1 isoform X18

      UniProtKB/TrEMBL
      A0A8L2RC24
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    RNA

    1. XR_010052051.1 RNA Sequence

    2. XR_005505437.2 RNA Sequence

    3. XR_005505438.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37285.2 GenPept UniProtKB/Swiss-Prot:P37285

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