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    Cndp2 carnosine dipeptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291394, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cndp2provided by RGD
    Official Full Name
    carnosine dipeptidase 2provided by RGD
    Primary source
    RGD:1305827
    See related
    Ensembl:ENSRNOG00000015591 AllianceGenome:RGD:1305827
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 960.0), Lung (RPKM 294.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    18q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (80314799..80331900, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (78039924..78057030, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (81521966..81539065, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene carnosine dipeptidase 1 Neighboring gene divergent protein kinase domain 1C Neighboring gene preferentially expressed antigen in melanoma-like 7, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assignment of the gene for dipeptidase 2 to Mus musculus chromosome 18 by somatic cell hybridization. Leinwand LA, et al. Biochem Genet, 1978 Jun. PMID 736882
    2. Electrophoretic heterogeneity of mouse erythrocyte peptidases. Lewis WH, et al. Biochem Genet, 1969 Oct. PMID 4187938
    3. Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Kozak C, et al. Somatic Cell Genet, 1975 Oct. PMID 1235912
    4. Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Kozak CA, et al. Somatic Cell Genet, 1977 Mar. PMID 204065
    5. Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Francke U, et al. Cytogenet Cell Genet, 1977. PMID 198184

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alanylglutamate dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallodipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic non-specific dipeptidase
    Names
    CNDP dipeptidase 2 (metallopeptidase M20 family)
    cytosolic nonspecific dipeptidase 2
    threonyl dipeptidase
    NP_001010920.1
    XP_006255061.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010920.1 → NP_001010920.1  cytosolic non-specific dipeptidase

      See identical proteins and their annotated locations for NP_001010920.1

      Status: PROVISIONAL

      Source sequence(s)
      AY569013
      UniProtKB/Swiss-Prot
      Q6Q0N1
      UniProtKB/TrEMBL
      A6K5L5
      Conserved Domains (2) summary
      PRK08201
      Location:3 → 473
      PRK08201; hypothetical protein; Provisional
      cd05676
      Location:7 → 473
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      80314799..80331900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254999.5 → XP_006255061.1  cytosolic non-specific dipeptidase isoform X1

      See identical proteins and their annotated locations for XP_006255061.1

      UniProtKB/Swiss-Prot
      Q6Q0N1
      UniProtKB/TrEMBL
      A6K5L5
      Related
      ENSRNOP00000021400.3
      Conserved Domains (2) summary
      PRK08201
      Location:3 → 473
      PRK08201; hypothetical protein; Provisional
      cd05676
      Location:7 → 473
      M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Q0N1.1 GenPept UniProtKB/Swiss-Prot:Q6Q0N1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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