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    G3bp1 G3BP stress granule assembly factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171092, updated on 30-Mar-2024

    Summary

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    Official Symbol
    G3bp1provided by RGD
    Official Full Name
    G3BP stress granule assembly factor 1provided by RGD
    Primary source
    RGD:621140
    See related
    Ensembl:ENSRNOG00000013186 AllianceGenome:RGD:621140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G3bp; RGD1310666
    Summary
    Predicted to enable helicase activity and mRNA binding activity. Predicted to be involved in several processes, including positive regulation of stress granule assembly; positive regulation of type I interferon production; and stress granule assembly. Predicted to act upstream of or within negative regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasmic stress granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 268.3), Heart (RPKM 252.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See G3bp1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (40087533..40120931)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39586864..39620268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40812858..40846252)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene antioxidant 1 copper chaperone Neighboring gene small nucleolar RNA, H/ACA box 29 Neighboring gene glycine receptor, alpha 1 Neighboring gene protein UXT pseudogene Neighboring gene high mobility group box 1 like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Sahoo PK, et al. Nat Commun, 2018 Aug 22. PMID 30135423, Free PMC Article
    2. G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration. Li S, et al. Cell Prolif, 2023 Mar. PMID 36450665, Free PMC Article
    3. Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation. Visser LJ, et al. J Virol, 2019 Jan 15. PMID 30404792, Free PMC Article
    4. Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication. Cristea IM, et al. J Virol, 2010 Jul. PMID 20392851, Free PMC Article
    5. The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response. Kim SS, et al. J Biol Chem, 2019 Apr 19. PMID 30804210, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translation initiating factor eIF4E and arginine methylation underlie G3BP1 function in dendritic spine development of neurons.
      Title: The translation initiating factor eIF4E and arginine methylation underlie G3BP1 function in dendritic spine development of neurons.
    2. G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
      Title: G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
    3. A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2alpha Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
      Title: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
    4. Data show that axotomy of mammalian neurons induces translation of stored axonal mRNAs via regulation of the stress granule protein G3BP1, to support regeneration of peripheral nerves.
      Title: Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration.
    5. Two related proteins found in association with nsP4 at both times of infection, GTPase-activating protein (SH3 domain) binding protein 1 (G3BP1) and G3BP2 were also previously identified as associated with sindbis virus nsP2 and nsP3.
      Title: Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: role for G3BP1 and G3BP2 in virus replication.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA/RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein-binding protein 1
    Names
    GTPase activating protein (SH3 domain) binding protein 1
    Ras-GTPase-activating protein SH3-domain binding protein 1
    NP_598249.1
    XP_038941049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133565.1 → NP_598249.1  ras GTPase-activating protein-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A7W1, D3ZYS7
      Related
      ENSRNOP00000018149.4, ENSRNOT00000018149.7
      Conserved Domains (3) summary
      PHA03247
      Location:216 → 328
      PHA03247; large tegument protein UL36; Provisional
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12463
      Location:335 → 414
      RRM_G3BP1; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      40087533..40120931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085121.2 → XP_038941049.1  ras GTPase-activating protein-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7W1, D3ZYS7
      Conserved Domains (3) summary
      PHA03247
      Location:216 → 328
      PHA03247; large tegument protein UL36; Provisional
      cd00780
      Location:7 → 135
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12463
      Location:335 → 414
      RRM_G3BP1; RNA recognition motif (RRM) found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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