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    Ndufb1 NADH:ubiquinone oxidoreductase subunit B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912357, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ndufb1provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B1provided by RGD
    Primary source
    RGD:6487218
    See related
    AllianceGenome:RGD:6487218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CI-MNLL
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrion and nuclear speck. Predicted to be part of mitochondrial respiratory chain complex I. Orthologous to human NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 1460.3), Muscle (RPKM 1177.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndufb1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (126880537..126888935, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121115649..121124055, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (125861219..125870231, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103604 Neighboring gene ribosomal protein L37A, pseudogene 6 Neighboring gene uncharacterized LOC134479251 Neighboring gene ataxin 3 Neighboring gene LLP homolog, long-term synaptic facilitation factor, pseudogene 1 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene solute carrier family 24 member 4 Neighboring gene Ras and Rab interactor 3 Neighboring gene uncharacterized LOC134479252

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. Stroud DA, et al. Nature, 2016 Oct 6. PMID 27626371
    2. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. Murray J, et al. J Biol Chem, 2003 Apr 18. PMID 12611891
    3. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    Names
    Complex I-MNLL
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    NADH-ubiquinone oxidoreductase MNLL subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402546.1 → NP_001389475.1  nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P0DN35
      UniProtKB/TrEMBL
      A6JEJ6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      126880537..126888935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056985555.2 → XP_056841535.1  nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      P0DN35
      UniProtKB/TrEMBL
      A6JEJ6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DN35.1 GenPept UniProtKB/Swiss-Prot:P0DN35

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.