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    Gas2l3 growth arrest-specific 2 like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680280, updated on 3-Apr-2024

    Summary

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    Symbol
    Gas2l3provided by RGD
    Full Name
    growth arrest-specific 2 like 3provided by RGD
    Primary source
    RGD:1594151
    See related
    Ensembl:ENSRNOG00000063755 AllianceGenome:RGD:1594151
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity; cytoskeletal anchor activity; and microtubule binding activity. Predicted to be involved in actin crosslink formation and microtubule cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Predicted to be located in actin cytoskeleton and microtubule cytoskeleton. Predicted to be active in actin filament. Orthologous to human GAS2L3 (growth arrest specific 2 like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 32.1), Thymus (RPKM 17.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gas2l3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (25690929..25726806, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (23803578..23836816, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (29963129..29996021, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene nuclear receptor subfamily 1, group H, member 4 Neighboring gene Annexin A7, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of G2L3 (GAS2-like 3), a new microtubule- and actin-binding protein related to spectraplakins. Stroud MJ, et al. J Biol Chem, 2011 Jul 15. PMID 21561867, Free PMC Article
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GAS2-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      25690929..25726806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595199.3 → XP_017450688.1  GAS2-like protein 3

      UniProtKB/TrEMBL
      A0A8I6AL26
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_008765306.4 → XP_008763528.1  GAS2-like protein 3

      See identical proteins and their annotated locations for XP_008763528.1

      UniProtKB/TrEMBL
      A0A8I6AL26
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily

    3. XM_008765308.4 → XP_008763530.1  GAS2-like protein 3

      See identical proteins and their annotated locations for XP_008763530.1

      UniProtKB/TrEMBL
      A0A8I6AL26
      Related
      ENSRNOP00000094564.1
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily

    4. XM_017595198.3 → XP_017450687.1  GAS2-like protein 3

      UniProtKB/TrEMBL
      A0A8I6AL26
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily

    5. XM_039080081.2 → XP_038936009.1  GAS2-like protein 3

      UniProtKB/TrEMBL
      A0A8I6AL26
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily

    6. XM_063264406.1 → XP_063120476.1  GAS2-like protein 3

      UniProtKB/TrEMBL
      A0A8I6AL26

    7. XM_001056437.8 → XP_001056437.2  GAS2-like protein 3

      See identical proteins and their annotated locations for XP_001056437.2

      UniProtKB/TrEMBL
      A0A8I6AL26
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily

    8. XM_006241237.5 → XP_006241299.1  GAS2-like protein 3

      See identical proteins and their annotated locations for XP_006241299.1

      UniProtKB/TrEMBL
      A0A8I6AL26
      Conserved Domains (3) summary
      PHA03247
      Location:306 → 645
      PHA03247; large tegument protein UL36; Provisional
      pfam02187
      Location:215 → 283
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:46 → 174
      CH_SF; calponin homology (CH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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