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    Ttll11 tubulin tyrosine ligase like11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689746, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Ttll11provided by RGD
    Official Full Name
    tubulin tyrosine ligase like11provided by RGD
    Primary source
    RGD:1588742
    See related
    Ensembl:ENSRNOG00000019339 AllianceGenome:RGD:1588742
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within microtubule severing and protein polyglutamylation. Predicted to be located in ciliary basal body. Orthologous to human TTLL11 (tubulin tyrosine ligase like 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 30.7), Testes (RPKM 27.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttll11 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (39507714..39732893, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (19109891..19335077, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (15084244..15312312, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101533 Neighboring gene ribosomal protein S16, pseudogene 8 Neighboring gene DAB2 interacting protein Neighboring gene uncharacterized LOC134486078 Neighboring gene uncharacterized LOC134486079 Neighboring gene uncharacterized LOC120101534 Neighboring gene uncharacterized LOC108350358 Neighboring gene uncharacterized LOC120101535 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. Lacroix B, et al. J Cell Biol, 2010 Jun 14. PMID 20530212, Free PMC Article
    2. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189441

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule severing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase TTLL11
    Names
    tubulin tyrosine ligase-like family, member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      39507714..39732893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284853.1 → XP_063140923.1  tubulin polyglutamylase TTLL11 isoform X4

    2. XM_017592137.3 → XP_017447626.3  tubulin polyglutamylase TTLL11 isoform X3

    3. XM_001071863.8 → XP_001071863.5  tubulin polyglutamylase TTLL11 isoform X2

      UniProtKB/TrEMBL
      A0A8J8YGC3

    4. XM_017592136.3 → XP_017447625.3  tubulin polyglutamylase TTLL11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD63

    5. XM_063284855.1 → XP_063140925.1  tubulin polyglutamylase TTLL11 isoform X7

      UniProtKB/TrEMBL
      A6JUG2, B5DFG3, F1LPS9

    6. XM_039106239.2 → XP_038962167.1  tubulin polyglutamylase TTLL11 isoform X6

      UniProtKB/TrEMBL
      A6JUG2
      Conserved Domains (1) summary
      cl17255
      Location:1 → 261
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    7. XM_039106238.2 → XP_038962166.2  tubulin polyglutamylase TTLL11 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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