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    Ttl tubulin tyrosine ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171572, updated on 2-May-2024

    Summary

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    Official Symbol
    Ttlprovided by RGD
    Official Full Name
    tubulin tyrosine ligaseprovided by RGD
    Primary source
    RGD:621113
    See related
    Ensembl:ENSRNOG00000018205 AllianceGenome:RGD:621113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables tubulin-tyrosine ligase activity. Predicted to be involved in C-terminal protein-tyrosinylation; positive regulation of mitotic cell cycle; and regulation of metaphase plate congression. Predicted to act upstream of or within microtubule cytoskeleton organization and regulation of axon extension. Predicted to be located in spindle microtubule. Orthologous to human TTL (tubulin tyrosine ligase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 217.2), Brain (RPKM 144.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttl in Genome Data Viewer
    Location:
    3q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136752025..136781758)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (116298813..116328538)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121596773..121626581)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, pseudogene 1 Neighboring gene zinc finger CCCH type containing 6 Neighboring gene vinculin/alpha-catenin family member 1 Neighboring gene RNA polymerase I subunit B Neighboring gene uncharacterized LOC134486439 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of rat olfactory bulb tubulin tyrosine ligase cDNA: a dominant negative mutant and an antisense cDNA increase the proliferation rate of cells in culture. Mas CR, et al. Neurochem Res, 2002 Nov. PMID 12512949
    2. Tubulin tyrosine ligase: protein and mRNA expression in developing rat skeletal muscle. Arregui CO, et al. Dev Growth Differ, 1997 Apr. PMID 9108330
    3. A vital role of tubulin-tyrosine-ligase for neuronal organization. Erck C, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15899979, Free PMC Article
    4. Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Barisic M, et al. Science, 2015 May 15. PMID 25908662, Free PMC Article
    5. Characterization of the tubulin-tyrosine ligase. Ersfeld K, et al. J Cell Biol, 1993 Feb. PMID 8093886, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin-tyrosine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-tyrosine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tubulin-tyrosine ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin-tyrosine ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of metaphase plate congression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin--tyrosine ligase
    NP_612545.2
    XP_006235008.1
    XP_038960141.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138536.2 → NP_612545.2  tubulin--tyrosine ligase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9QXJ0, Q9Z1E5
      UniProtKB/TrEMBL
      A6HQ46, G3V8C8
      Related
      ENSRNOP00000024695.5, ENSRNOT00000024694.7
      Conserved Domains (1) summary
      pfam03133
      Location:81 → 366
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      136752025..136781758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104213.2 → XP_038960141.1  tubulin--tyrosine ligase isoform X2

      UniProtKB/Swiss-Prot
      Q9QXJ0, Q9Z1E5
      Conserved Domains (1) summary
      pfam03133
      Location:81 → 339
      TTL; Tubulin-tyrosine ligase family

    2. XM_006234946.5 → XP_006235008.1  tubulin--tyrosine ligase isoform X1

      UniProtKB/Swiss-Prot
      Q9QXJ0, Q9Z1E5
      Related
      ENSRNOP00000090593.1
      Conserved Domains (1) summary
      pfam03133
      Location:81 → 348
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QXJ0.1 GenPept UniProtKB/Swiss-Prot:Q9QXJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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