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    Nuak2 NUAK family kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289419, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nuak2provided by RGD
    Official Full Name
    NUAK family kinase 2provided by RGD
    Primary source
    RGD:1359167
    See related
    Ensembl:ENSRNOG00000000034 AllianceGenome:RGD:1359167
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Snark; UV126; 1200013b22rik
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose starvation and protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 251.3), Adrenal (RPKM 38.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nuak2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46305744..46322755)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43753454..43770604)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (49092306..49109055)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene BLACAT1 overlapping LEMD1 locus Neighboring gene microRNA 135b Neighboring gene LEM domain containing 1 Neighboring gene kelch domain containing 8A Neighboring gene uncharacterized LOC120096185 Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene dual serine/threonine and tyrosine protein kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of SNARK activity in response to cellular stresses. Lefebvre DL, et al. Biochim Biophys Acta, 2005 Jun 20. PMID 15893879
    2. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Suzuki A, et al. Biochem Biophys Res Commun, 2003 Nov 7. PMID 14575707
    3. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Lefebvre DL, et al. Biochem J, 2001 Apr 15. PMID 11284715, Free PMC Article
    4. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. Legembre P, et al. J Biol Chem, 2004 Nov 5. PMID 15345718
    5. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. Humbert N, et al. EMBO J, 2010 Jan 20. PMID 19927127, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93817

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hippo signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NUAK family SNF1-like kinase 2
    Names
    NUAK family, SNF1-like kinase, 2
    SNF1/AMP kinase-related kinase
    SNF1/AMP-activated protein kinase
    NP_001007618.1
    XP_038946542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007617.1 → NP_001007618.1  NUAK family SNF1-like kinase 2

      See identical proteins and their annotated locations for NP_001007618.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081899
      UniProtKB/Swiss-Prot
      Q66HE5
      UniProtKB/TrEMBL
      A0A8I6AQK6, A6IC48
      Related
      ENSRNOP00000000039.2, ENSRNOT00000000039.4
      Conserved Domains (2) summary
      smart00220
      Location:57 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:53 → 307
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      46305744..46322755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090614.2 → XP_038946542.1  NUAK family SNF1-like kinase 2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:53 → 307
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HE5.1 GenPept UniProtKB/Swiss-Prot:Q66HE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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