Slc5a12 solute carrier family 5 member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a12provided by RGD
Official Full Name: solute carrier family 5 member 12provided by RGD
Primary source: RGD:1311652
See related: Ensembl:ENSRNOG00000028008 AllianceGenome:RGD:1311652
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311652
Summary: Predicted to enable lactate transmembrane transporter activity and symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SLC5A12 (solute carrier family 5 member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 795.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (117633885..117683966)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (97179326..97228405)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (101791336..101833044)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lactate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables salt transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables symporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lactate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled monocarboxylate transporter 2

Names: solute carrier family 5 (sodium/glucose cotransporter), member 12; solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108588.1 → NP_001102058.1 sodium-coupled monocarboxylate transporter 2

See identical proteins and their annotated locations for NP_001102058.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A0A8I6ARH5, A6HP16, F1LWL8

Related

ENSRNOP00000041926.4, ENSRNOT00000046937.5

Conserved Domains (1) summary

cd11520
Location:3 → 527

SLC5sbd_SMCT2; Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain