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    Dhx58 DEXH-box helicase 58 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303538, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dhx58provided by RGD
    Official Full Name
    DEXH-box helicase 58provided by RGD
    Primary source
    RGD:1310093
    See related
    Ensembl:ENSRNOG00000018247 AllianceGenome:RGD:1310093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lgp2; RGD1310093
    Summary
    Predicted to enable double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Predicted to act upstream of or within response to bacterium. Predicted to be active in cytoplasm. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 62.6), Lung (RPKM 48.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhx58 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86120677..86132095, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85620352..85631776, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88599722..88611562, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 10 C17orf113 homolog pseudogene Neighboring gene uncharacterized LOC120095293 Neighboring gene lysine acetyltransferase 2A Neighboring gene heat shock protein family B (small) member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. Li X, et al. J Biol Chem, 2009 May 15. PMID 19278996, Free PMC Article
    2. Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response. Murali A, et al. J Biol Chem, 2008 Jun 6. PMID 18411269, Free PMC Article
    3. Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. Venkataraman T, et al. J Immunol, 2007 May 15. PMID 17475874
    4. Ambivalent role of the innate immune response in rabies virus pathogenesis. Chopy D, et al. J Virol, 2011 Jul. PMID 21525357, Free PMC Article
    5. LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Satoh T, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080593, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional analysis of the human LGP2 ortholog.
      Title: RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DHX58
    Names
    DEXH (Asp-Glu-X-His) box polypeptide 58
    RNA helicase LGP2
    probable ATP-dependent RNA helicase DHX58
    NP_001092258.1
    XP_006247376.1
    XP_006247377.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098788.1 → NP_001092258.1  ATP-dependent RNA helicase DHX58

      See identical proteins and their annotated locations for NP_001092258.1

      Status: VALIDATED

      Source sequence(s)
      BP488074, CB544595, CB546277, CR460878, JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZD46
      Related
      ENSRNOP00000024718.4, ENSRNOT00000024718.6
      Conserved Domains (4) summary
      cd15806
      Location:552 → 664
      LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
      cd12090
      Location:227 → 342
      MDA5_ID; Insert domain of MDA5
      cd18802
      Location:349 → 483
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:1 → 200
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86120677..86132095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247314.5 → XP_006247376.1  ATP-dependent RNA helicase DHX58 isoform X1

      See identical proteins and their annotated locations for XP_006247376.1

      UniProtKB/TrEMBL
      D3ZD46
      Conserved Domains (4) summary
      cd15806
      Location:552 → 664
      LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
      cd12090
      Location:227 → 342
      MDA5_ID; Insert domain of MDA5
      cd18802
      Location:349 → 483
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:1 → 200
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. XM_006247315.5 → XP_006247377.1  ATP-dependent RNA helicase DHX58 isoform X1

      See identical proteins and their annotated locations for XP_006247377.1

      UniProtKB/TrEMBL
      D3ZD46
      Conserved Domains (4) summary
      cd15806
      Location:552 → 664
      LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor
      cd12090
      Location:227 → 342
      MDA5_ID; Insert domain of MDA5
      cd18802
      Location:349 → 483
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:1 → 200
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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