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    Raph1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363239, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Raph1provided by RGD
    Official Full Name
    Ras association (RalGDS/AF-6) and pleckstrin homology domains 1provided by RGD
    Primary source
    RGD:1308387
    See related
    Ensembl:ENSRNOG00000014722 AllianceGenome:RGD:1308387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in signal transduction. Predicted to act upstream of or within axon extension. Predicted to be located in cell leading edge and nuclear body. Predicted to be active in cytosol and plasma membrane. Orthologous to human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 138.8), Liver (RPKM 131.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Raph1 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (69397272..69484174, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61907476..61990170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (67290004..67370208, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 2, pseudogene 1 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene abl-interactor 2 Neighboring gene uncharacterized LOC102547711 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis. Michael M, et al. Curr Biol, 2010 May 11. PMID 20417104, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-associated and pleckstrin homology domains-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108798.2 → NP_001102268.2  ras-associated and pleckstrin homology domains-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZU51
      Related
      ENSRNOP00000081933.1, ENSRNOT00000102881.1
      Conserved Domains (3) summary
      cd01259
      Location:393 → 515
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:398 → 506
      PH; PH domain
      cl00155
      Location:270 → 351
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      69397272..69484174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267382.1 → XP_063123452.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      A6IPD1

    2. XM_063267381.1 → XP_063123451.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      D4ADX8

    3. XM_039083870.2 → XP_038939798.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      D4ADX8
      Conserved Domains (2) summary
      cd01259
      Location:445 → 567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320 → 409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    4. XM_039083868.2 → XP_038939796.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AMM7, A6IPC9
      Conserved Domains (2) summary
      cd01259
      Location:445 → 567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320 → 409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    5. XM_039083863.2 → XP_038939791.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL54
      Related
      ENSRNOP00000078550.1
      Conserved Domains (2) summary
      cd01259
      Location:418 → 540
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:293 → 382
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    6. XM_039083862.2 → XP_038939790.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AF23
      Related
      ENSRNOP00000093050.1
      Conserved Domains (2) summary
      cd01259
      Location:420 → 542
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:295 → 384
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    7. XM_039083861.2 → XP_038939789.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A272
      Related
      ENSRNOP00000084951.1
      Conserved Domains (2) summary
      cd01259
      Location:445 → 567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320 → 409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    8. XM_063267379.1 → XP_063123449.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AMM7

    9. XM_063267380.1 → XP_063123450.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AMM7

    10. XM_039083864.2 → XP_038939792.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X4

      Conserved Domains (2) summary
      cd01259
      Location:384 → 506
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:259 → 348
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    11. XM_039083866.1 → XP_038939794.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X5

    12. XM_039083869.2 → XP_038939797.1  ras-associated and pleckstrin homology domains-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      D4ADX8
      Conserved Domains (2) summary
      cd01259
      Location:445 → 567
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16136
      Location:320 → 409
      RA_MRL_Lpd; Ras-associating (RA) domain found in the adapter protein lamellipodin (Lpd)

    RNA

    1. XR_005488933.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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