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    Rcan1 regulator of calcineurin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266766, updated on 11-Apr-2024

    Summary

    Official Symbol
    Rcan1provided by RGD
    Official Full Name
    regulator of calcineurin 1provided by RGD
    Primary source
    RGD:631338
    See related
    Ensembl:ENSRNOG00000001979 AllianceGenome:RGD:631338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dscr1; Mcip1
    Summary
    Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity and identical protein binding activity. Involved in several processes, including negative regulation of smooth muscle cell differentiation; response to estrogen; and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of calcineurin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 639.6), Liver (RPKM 480.3) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rcan1 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (45108123..45188065, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (31622208..31702150, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (32539689..32620274, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 34 Neighboring gene uncharacterized LOC108352307 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 1 Neighboring gene uncharacterized LOC134480974 Neighboring gene chloride intracellular channel 6 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase 2B binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in locomotion involved in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within locomotion involved in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of calcineurin-NFAT signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to estrogen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in short-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within short-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcipressin-1
    Names
    Down syndrome critical region gene 1
    Down syndrome critical region homolog 1
    down syndrome critical region protein 1 homolog
    myocyte-enriched calcineurin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153724.2NP_714946.2  calcipressin-1

      See identical proteins and their annotated locations for NP_714946.2

      Status: PROVISIONAL

      Source sequence(s)
      BC072478
      UniProtKB/Swiss-Prot
      Q6IN33, Q8K4S2
      UniProtKB/TrEMBL
      A6JLK0
      Related
      ENSRNOP00000002715.4, ENSRNOT00000002715.7
      Conserved Domains (1) summary
      pfam04847
      Location:22192
      Calcipressin; Calcipressin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      45108123..45188065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248041.5XP_006248103.1  calcipressin-1 isoform X1

      See identical proteins and their annotated locations for XP_006248103.1

      UniProtKB/TrEMBL
      A0A8I6AFT2, A6JLJ9
      Related
      ENSRNOP00000092573.1
      Conserved Domains (1) summary
      pfam04847
      Location:74244
      Calcipressin; Calcipressin