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    Inpp5a inositol polyphosphate-5-phosphatase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365382, updated on 13-Apr-2024

    Summary

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    Symbol
    Inpp5aprovided by RGD
    Full Name
    inositol polyphosphate-5-phosphatase Aprovided by RGD
    Primary source
    RGD:1306168
    See related
    Ensembl:ENSRNOG00000017635 AllianceGenome:RGD:1306168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables inositol-polyphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; inositol phosphate-mediated signaling; and negative regulation of neuron death. Located in dendrite. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 402.0), Lung (RPKM 176.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inpp5a in Genome Data Viewer
    Location:
    1q41
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203619676..203810035)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194190086..194380429)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211732163..211920844)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485195 Neighboring gene uncharacterized LOC134485196 Neighboring gene uncharacterized LOC134485194 Neighboring gene NK6 homeobox 2 Neighboring gene cilia and flagella associated protein 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Post-translational modification of human brain type I inositol-1,4,5-trisphosphate 5-phosphatase by farnesylation. De Smedt F, et al. J Biol Chem, 1996 Apr 26. PMID 8626616
    2. Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase. Laxminarayan KM, et al. J Biol Chem, 1994 Jun 24. PMID 8006039
    3. Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I. Auethavekiat V, et al. J Biol Chem, 1997 Jan 17. PMID 8999861
    4. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PH domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate-5-phosphatase A
    Names
    5PTase
    type I inositol 1,4,5-trisphosphate 5-phosphatase
    type I inositol 1,4,5-trisphosphate 5-phosphatase-like
    NP_001102393.1
    XP_006230548.1
    XP_063125749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108923.2 → NP_001102393.1  inositol polyphosphate-5-phosphatase A

      See identical proteins and their annotated locations for NP_001102393.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZZX1
      Related
      ENSRNOP00000051774.2, ENSRNOT00000054890.5
      Conserved Domains (1) summary
      cd09092
      Location:10 → 394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203619676..203810035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230486.4 → XP_006230548.1  inositol polyphosphate-5-phosphatase A isoform X1

      See identical proteins and their annotated locations for XP_006230548.1

      UniProtKB/TrEMBL
      A6HXB9
      Conserved Domains (1) summary
      cd09092
      Location:10 → 394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    2. XM_063269679.1 → XP_063125749.1  inositol polyphosphate-5-phosphatase A isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZZX1.1 GenPept UniProtKB/Swiss-Prot:D3ZZX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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