Slbp stem-loop histone mRNA binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slbpprovided by RGD
Official Full Name: stem-loop histone mRNA binding proteinprovided by RGD
Primary source: RGD:1584682
See related: Ensembl:ENSRNOG00000037162 AllianceGenome:RGD:1584682
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone pre-mRNA stem-loop binding activity; identical protein binding activity; and mRNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA transport. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of histone pre-mRNA 3'end processing complex. Predicted to be active in cytoplasm. Orthologous to human SLBP (stem-loop binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 481.9), Spleen (RPKM 437.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (81295479..81306446)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (77071441..77081911)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82356916..82366368)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone pre-mRNA stem-loop binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone pre-mRNA stem-loop binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cap-dependent translational initiation	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA 3'-end processing by stem-loop binding and cleavage	ISO Inferred from Sequence Orthology more info
involved_in mRNA transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone mRNA stem-loop binding complex	ISO Inferred from Sequence Orthology more info
part_of histone pre-mRNA 3'end processing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone pre-mRNA 3'end processing complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone RNA hairpin-binding protein

Names: stem-loop binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130988.1 → NP_001124460.1 histone RNA hairpin-binding protein

See identical proteins and their annotated locations for NP_001124460.1

Status: PROVISIONAL

Source sequence(s)

BC167755

UniProtKB/TrEMBL

A0A8I6AID5, A0A9K3Y6R4, A6IK58, B3DM97, D3ZSM2

Related

ENSRNOP00000047799.3, ENSRNOT00000040229.4

Conserved Domains (1) summary

pfam15247
Location:130 → 197

SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

81295479..81306446

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092440.2 → XP_038948368.1 histone RNA hairpin-binding protein isoform X1

UniProtKB/TrEMBL

A0A8I6AID5, A6IK58, A6IK59

Conserved Domains (1) summary

pfam15247
Location:95 → 163

SLBP_RNA_bind; Histone RNA hairpin-binding protein RNA-binding domain