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    Nostrin nitric oxide synthase trafficking [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311111, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nostrinprovided by RGD
    Official Full Name
    nitric oxide synthase traffickingprovided by RGD
    Primary source
    RGD:727920
    See related
    Ensembl:ENSRNOG00000006611 AllianceGenome:RGD:727920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Orthologous to human NOSTRIN (nitric oxide synthase trafficking). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 299.3), Liver (RPKM 71.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nostrin in Genome Data Viewer
    Location:
    3q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74312594..74378852)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (53904746..53970995)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55369282..55433840)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ceramide synthase 6 Neighboring gene uncharacterized LOC134486099 Neighboring gene Y box binding protein 1, pseudogene 9 Neighboring gene SPC25 component of NDC80 kinetochore complex Neighboring gene glucose-6-phosphatase catalytic subunit 2 Neighboring gene ATP binding cassette subfamily B member 11 Neighboring gene DNA mismatch repair protein Msh6-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mouse disabled 2 interacting protein 2 functions as a transcriptional repressor through direct binding onto its own promoter. Kim HW, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16171775
    2. Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats. Kirsch T, et al. Brain Res, 2001 Aug 10. PMID 11489260
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nostrin
    Names
    BM247
    eNOS-trafficking inducer
    nitric oxide synthase trafficker

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024260.1 → NP_001019431.1  nostrin

      See identical proteins and their annotated locations for NP_001019431.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088446
      UniProtKB/Swiss-Prot
      Q5I0D6, Q923J7
      UniProtKB/TrEMBL
      A0A8I6AC89
      Related
      ENSRNOP00000062066.2, ENSRNOT00000067161.4
      Conserved Domains (2) summary
      cd11823
      Location:443 → 494
      SH3_Nostrin; Src homology 3 domain of Nitric Oxide Synthase TRaffic INducer
      cl12013
      Location:8 → 250
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      74312594..74378852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104842.2 → XP_038960770.1  nostrin isoform X1

      Conserved Domains (1) summary
      cl12013
      Location:8 → 211
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5I0D6.1 GenPept UniProtKB/Swiss-Prot:Q5I0D6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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