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    Tmc8 transmembrane channel-like 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688276, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmc8provided by RGD
    Official Full Name
    transmembrane channel-like 8provided by RGD
    Primary source
    RGD:1591150
    See related
    Ensembl:ENSRNOG00000046086 AllianceGenome:RGD:1591150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mechanosensitive ion channel activity; protein sequestering activity; and tumor necrosis factor binding activity. Predicted to be involved in several processes, including negative regulation of protein binding activity; regulation of extrinsic apoptotic signaling pathway via death domain receptors; and zinc ion homeostasis. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC8 (transmembrane channel like 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 153.7), Spleen (RPKM 86.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmc8 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103498505..103509496)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103000038..103010601)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106784819..106795307)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6C Neighboring gene transmembrane channel like 6 Neighboring gene smilar to human chromosome 17 open reading frame 99 Neighboring gene U6 spliceosomal RNA Neighboring gene synaptogyrin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Ramoz N, et al. Nat Genet, 2002 Dec. PMID 12426567
    2. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. Lazarczyk M, et al. J Exp Med, 2008 Jan 21. PMID 18158319, Free PMC Article
    3. EVER2 protein binds TRADD to promote TNF-α-induced apoptosis. Gaud G, et al. Cell Death Dis, 2013 Feb 21. PMID 23429285, Free PMC Article
    4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tumor necrosis factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126301.1 → NP_001119773.1  transmembrane channel-like protein 8

      See identical proteins and their annotated locations for NP_001119773.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160873
      UniProtKB/TrEMBL
      B1H258, M0RE13
      Related
      ENSRNOP00000067877.2, ENSRNOT00000075047.2
      Conserved Domains (1) summary
      pfam07810
      Location:428 → 529
      TMC; TMC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103498505..103509496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247821.5 → XP_006247883.1  transmembrane channel-like protein 8 isoform X3

      See identical proteins and their annotated locations for XP_006247883.1

      UniProtKB/TrEMBL
      M0RE13
      Conserved Domains (1) summary
      pfam07810
      Location:423 → 533
      TMC; TMC domain

    2. XM_008768392.4 → XP_008766614.1  transmembrane channel-like protein 8 isoform X3

      See identical proteins and their annotated locations for XP_008766614.1

      UniProtKB/TrEMBL
      M0RE13
      Conserved Domains (1) summary
      pfam07810
      Location:423 → 533
      TMC; TMC domain

    3. XM_039086848.2 → XP_038942776.1  transmembrane channel-like protein 8 isoform X4

    4. XM_039086849.2 → XP_038942777.1  transmembrane channel-like protein 8 isoform X5

    5. XM_006247819.5 → XP_006247881.1  transmembrane channel-like protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACB7
      Conserved Domains (1) summary
      pfam07810
      Location:493 → 594
      TMC; TMC domain

    6. XM_039086846.2 → XP_038942774.1  transmembrane channel-like protein 8 isoform X3

      UniProtKB/TrEMBL
      M0RE13
      Conserved Domains (1) summary
      pfam07810
      Location:423 → 533
      TMC; TMC domain

    7. XM_006247818.5 → XP_006247880.1  transmembrane channel-like protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACB7
      Conserved Domains (1) summary
      pfam07810
      Location:494 → 595
      TMC; TMC domain

    8. XM_039086847.2 → XP_038942775.1  transmembrane channel-like protein 8 isoform X3

      UniProtKB/TrEMBL
      M0RE13
      Conserved Domains (1) summary
      pfam07810
      Location:423 → 533
      TMC; TMC domain

    RNA

    1. XR_005489944.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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