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    Pga5 pepsinogen 5, group I [ Mus musculus (house mouse) ]

    Gene ID: 58803, updated on 11-Apr-2024

    Summary

    Official Symbol
    Pga5provided by MGI
    Official Full Name
    pepsinogen 5, group Iprovided by MGI
    Primary source
    MGI:MGI:1915935
    See related
    Ensembl:ENSMUSG00000024738 AllianceGenome:MGI:1915935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pepf; 1110035E17Rik
    Summary
    Enables aspartic-type endopeptidase activity. Predicted to act upstream of or within protein metabolic process. Predicted to be located in extracellular region. Is expressed in alimentary system epithelium; extraembryonic component; placenta; and stomach. Orthologous to several human genes including PGA4 (pepsinogen A4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward stomach adult (RPKM 68.7) See more
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    Genomic context

    Location:
    19 A; 19 7.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10646321..10655435, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10668957..10678071, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene triokinase, FMN cyclase Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains Neighboring gene STARR-seq mESC enhancer starr_45554 Neighboring gene RIKEN cDNA 2210404E10 gene Neighboring gene vacuolar protein sorting 37C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pepsin A-5
    Names
    pepsin F
    pepsinogen A5
    pepsinogen F
    NP_067428.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021453.4NP_067428.2  pepsin A-5 precursor

      See identical proteins and their annotated locations for NP_067428.2

      Status: VALIDATED

      Source sequence(s)
      AK053965, AK168924
      Consensus CDS
      CCDS29584.1
      UniProtKB/Swiss-Prot
      Q9D106, Q9JKE6
      Related
      ENSMUSP00000025647.6, ENSMUST00000025647.7
      Conserved Domains (3) summary
      pfam00026
      Location:74386
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:1644
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:64385
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10646321..10655435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)