Rnf112 ring finger protein 112 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf112provided by MGI
Official Full Name: ring finger protein 112provided by MGI
Primary source: MGI:MGI:106611
See related: Ensembl:ENSMUSG00000010086 AllianceGenome:MGI:106611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bfp; ZNF179; Zfp179; neurolastin
Summary: Enables several functions, including GTP binding activity; GTPase activity; and ubiquitin protein ligase activity. Involved in several processes, including cell death in response to hydrogen peroxide; embryonic brain development; and protein autoubiquitination. Acts upstream of or within G1 to G0 transition involved in cell differentiation; positive regulation of glial cell differentiation; and positive regulation of neuron differentiation. Located in several cellular components, including cytoplasmic vesicle; nuclear body; and postsynaptic density. Is extrinsic component of membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human RNF112 (ring finger protein 112). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 117.7), cortex adult (RPKM 98.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61339243..61345014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61448417..61454188, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Puralpha regulates the induction of Znf179 transcription during neuronal differentiation.
Title: Purα regulates the induction of Znf179 transcription during neuronal differentiation.
Rnf112 expression was highly involved in the progression of intracerebral hemorrhage.
Title: Rnf112 deletion protects brain against intracerebral hemorrhage (ICH) in mice by inhibiting TLR-4/NF-κB pathway.
Here the authors unveil the important role for the novel E3 ligase Znf179 in TDP-43-mediated neuropathy, and provide a potential therapeutic strategy for combating ALS/ FTLD-U neurodegenerative pathologies.
Title: Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.
Rnf112 protein is expressed in most brain areas and mainly in neurons; deletion of both Rnf112 alleles resulted in embryonic lethality associated with defects in embryonic vasculature; results provide evidence for the important functions of Rnf112 in embryo development and in adult brain
Title: Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions.
the results obtained in this study show that Znf179 autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF-induced Sp1 signaling may help attenuate more extensive (ROS-induced) damage following brain injury
Title: Specificity protein 1-zinc finger protein 179 pathway is involved in the attenuation of oxidative stress following brain injury.
Study focused on sigma-1 receptor (Sig-1R), a chaperone at endoplasmic reticulum, and investigated its protective functions; results reveal that zinc finger protein 179 plays a novel role in neuroprotection.
Title: The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury.
identify neurolastin as a dynamin family GTPase that affects endosome size and spine density.
Title: Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density.
This study provides the first evidence that ZNF179, PLZF, IGFBP3, and BIK contributed to the novel CEBPD-induced antiapoptotic feature of astrocytes.
Title: Increase of zinc finger protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease.
Induction of the Znf179 gene is associated with p35 expression and p27 protein accumulation, which lead to cell cycle arrest in the G0/G1 phase, and is critical for neuronal differentiation of P19 cells.
Title: A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125264 (e-PCR)
- UniSTS:162086

AI854096 (e-PCR)
- UniSTS:165763

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1 to G0 transition involved in cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to hydroperoxide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RING finger protein 112

Names: brain finger protein; zinc finger protein 179

NP_001277953.1

EC 2.3.2.27

NP_001346059.1

EC 2.3.2.27

NP_033574.2

EC 2.3.2.27

XP_006533241.1

EC 2.3.2.27

XP_006533243.1

EC 2.3.2.27

XP_006533244.1

EC 2.3.2.27

XP_006533245.1

EC 2.3.2.27

XP_006533246.1

EC 2.3.2.27

XP_006533247.1

EC 2.3.2.27

XP_006533248.1

EC 2.3.2.27

XP_017169993.1

EC 2.3.2.27

XP_017169994.1

EC 2.3.2.27

XP_030101793.1

EC 2.3.2.27

XP_036012528.1

EC 2.3.2.27

XP_036012529.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291024.1 → NP_001277953.1 RING finger protein 112 isoform 2

See identical proteins and their annotated locations for NP_001277953.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses alternate in-frame splice sites in the 5' coding region, compared to variant 3. It encodes isoform 2, which lacks two separate internal segments and is shorter, compared to isoform 3.

Source sequence(s)

BC013139, BY599807, CJ148450

Consensus CDS

CCDS78960.1

UniProtKB/Swiss-Prot

Q96DY5

Related

ENSMUSP00000099722.4, ENSMUST00000102661.4

Conserved Domains (2) summary

cd01851
Location:163 → 361

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd16538
Location:55 → 102

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
NM_001359130.1 → NP_001346059.1 RING finger protein 112 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AK131651, BC013139, BE945765, BY237309

Consensus CDS

CCDS88167.1

Related

ENSMUSP00000059903.8, ENSMUST00000060255.14

Conserved Domains (2) summary

cd16538
Location:78 → 125

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

cl38936
Location:186 → 409

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_009548.3 → NP_033574.2 RING finger protein 112 isoform 1

See identical proteins and their annotated locations for NP_033574.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses alternate in-frame splice sites in the 5' coding region, compared to variant 3. It encodes isoform 1, which lacks an internal segment and is shorter, compared to isoform 3.

Source sequence(s)

BC013139, BY599807, CJ148450

Consensus CDS

CCDS24812.1

UniProtKB/Swiss-Prot

Q3TNS6, Q5NCN2, Q8JZT5, Q96DY5, Q9Z328

Related

ENSMUSP00000056464.8, ENSMUST00000054927.14

Conserved Domains (2) summary

cd01851
Location:186 → 384

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd16538
Location:78 → 125

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61339243..61345014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314504.1 → XP_017169993.1 RING finger protein 112 isoform X6

Conserved Domains (2) summary

cd01851
Location:185 → 383

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd16538
Location:78 → 125

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
XM_006533180.2 → XP_006533243.1 RING finger protein 112 isoform X2

Conserved Domains (2) summary

cd16538
Location:78 → 125

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

cl38936
Location:185 → 408

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036156635.1 → XP_036012528.1 RING finger protein 112 isoform X4

Conserved Domains (2) summary

cd16538
Location:55 → 102

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

cl38936
Location:162 → 385

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006533183.2 → XP_006533246.1 RING finger protein 112 isoform X7

See identical proteins and their annotated locations for XP_006533246.1

UniProtKB/Swiss-Prot

Q96DY5

Conserved Domains (2) summary

cd01851
Location:163 → 361

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd16538
Location:55 → 102

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
XM_006533181.2 → XP_006533244.1 RING finger protein 112 isoform X3

Conserved Domains (2) summary

cd16538
Location:55 → 102

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

cl38936
Location:163 → 386

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_017314505.1 → XP_017169994.1 RING finger protein 112 isoform X9

Conserved Domains (1) summary

cd01851
Location:50 → 248

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
XM_006533185.2 → XP_006533248.1 RING finger protein 112 isoform X8

See identical proteins and their annotated locations for XP_006533248.1

Conserved Domains (1) summary

cl38936
Location:50 → 273

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006533182.5 → XP_006533245.1 RING finger protein 112 isoform X5

See identical proteins and their annotated locations for XP_006533245.1

UniProtKB/Swiss-Prot

Q3TNS6, Q5NCN2, Q8JZT5, Q96DY5, Q9Z328

Conserved Domains (2) summary

cd01851
Location:186 → 384

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

cd16538
Location:78 → 125

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins
XM_006533178.2 → XP_006533241.1 RING finger protein 112 isoform X1

See identical proteins and their annotated locations for XP_006533241.1

UniProtKB/Swiss-Prot

Q96DY5

Conserved Domains (2) summary

cd16538
Location:78 → 125

RING-HC_RNF112; RING finger, HC subclass, found in RING finger protein 112 (RNF112) and similar proteins

cl38936
Location:186 → 409

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_030245933.1 → XP_030101793.1 RING finger protein 112 isoform X9

Conserved Domains (1) summary

cd01851
Location:50 → 248

GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
XM_006533184.2 → XP_006533247.1 RING finger protein 112 isoform X8

See identical proteins and their annotated locations for XP_006533247.1

Conserved Domains (1) summary

cl38936
Location:50 → 273

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_036156636.1 → XP_036012529.1 RING finger protein 112 isoform X10

Conserved Domains (1) summary

cl38936
Location:1 → 161

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases