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    POLR3A RNA polymerase III subunit A [ Homo sapiens (human) ]

    Gene ID: 11128, updated on 26-Jan-2024

    Summary

    Official Symbol
    POLR3Aprovided by HGNC
    Official Full Name
    RNA polymerase III subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:30074
    See related
    Ensembl:ENSG00000148606 MIM:614258; AllianceGenome:HGNC:30074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADDH; C160; HLD7; RPC1; WDRTS; RPC155; hRPC155
    Summary
    The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in brain (RPKM 7.2), testis (RPKM 4.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See POLR3A in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (77975149..78029515, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (78844187..78898555, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79734907..79789273, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79688206-79688382 Neighboring gene DLG5 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79707975-79708512 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr10:79708513-79709050 and GRCh37_chr10:79709051-79709588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79730866-79731376 Neighboring gene H2A.Z histone pseudogene 5 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:79743812-79745011 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79784551-79785750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3613 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:79799147-79799658 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:79799659-79800168 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79800489-79800990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3614 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3616 Neighboring gene ribosomal protein S24 Neighboring gene G protein subunit alpha i2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of polymerase (RNA) III (DNA directed) polypeptide A, (POLR3A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables DNA/RNA hybrid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA-directed RNA polymerase III subunit RPC1
    Names
    DNA-directed RNA polymerase III largest subunit
    DNA-directed RNA polymerase III subunit A
    RNA polymerase III 155 kDa subunit
    RNA polymerase III subunit C1
    RNA polymerase III subunit C160
    RNA polymerase III subunit RPC155-D
    polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
    polymerase (RNA) III subunit A
    NP_008986.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029648.1 RefSeqGene

      Range
      5026..59392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007055.4NP_008986.2  DNA-directed RNA polymerase III subunit RPC1

      See identical proteins and their annotated locations for NP_008986.2

      Status: REVIEWED

      Source sequence(s)
      AK024744, AY091459, BC041089, CA449326, DA103416, DA353439
      Consensus CDS
      CCDS7354.1
      UniProtKB/Swiss-Prot
      O14802, Q8IW34, Q8TCW5
      UniProtKB/TrEMBL
      B7Z6H4
      Related
      ENSP00000361446.3, ENST00000372371.8
      Conserved Domains (3) summary
      cd02736
      Location:10211360
      RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
      CHL00117
      Location:8411058
      rpoC2; RNA polymerase beta'' subunit; Reviewed
      cd02583
      Location:24891
      RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      77975149..78029515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      78844187..78898555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)