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    ORC1 origin recognition complex subunit 1 [ Homo sapiens (human) ]

    Gene ID: 4998, updated on 4-Dec-2023

    Summary

    Official Symbol
    ORC1provided by HGNC
    Official Full Name
    origin recognition complex subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:8487
    See related
    Ensembl:ENSG00000085840 MIM:601902; AllianceGenome:HGNC:8487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ORC1L; PARC1; HSORC1
    Summary
    The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in bone marrow (RPKM 7.3), lymph node (RPKM 2.5) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ORC1 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52372829..52409503, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52254294..52290972, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (52838501..52870095, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancers GRCh37_chr1:52815874-52816848 and GRCh37_chr1:52816849-52817822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52822843-52823344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 887 Neighboring gene coiled-coil and C2 domain containing 1B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1031 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 889 Neighboring gene phospholipase A2 group XIIA pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:52869594-52870793 Neighboring gene uncharacterized LOC124904850 Neighboring gene Sharpr-MPRA regulatory region 15542 Neighboring gene pre-mRNA processing factor 38A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1032 Neighboring gene terminal uridylyl transferase 4 Neighboring gene MPRA-validated peak227 silencer Neighboring gene MPRA-validated peak228 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52963547-52964066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:52964067-52964586 Neighboring gene uncharacterized LOC105378723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 890

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    origin recognition complex subunit 1
    Names
    origin recognition complex, subunit 1 homolog
    replication control protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028251.2 RefSeqGene

      Range
      10080..41674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190818.2NP_001177747.1  origin recognition complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_001177747.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 5' UTR, resulting in 3 nt fewer than variant 1. Variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      BC011539, BP280383, U43416
      Consensus CDS
      CCDS566.1
      UniProtKB/Swiss-Prot
      D3DQ34, Q13415, Q13471, Q5T0F5
      UniProtKB/TrEMBL
      A8K794, Q96F82
      Related
      ENSP00000360621.1, ENST00000371566.1
      Conserved Domains (4) summary
      PRK10811
      Location:362487
      rne; ribonuclease E; Reviewed
      cd04719
      Location:44170
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      PTZ00112
      Location:495743
      PTZ00112; origin recognition complex 1 protein; Provisional
      pfam09079
      Location:778857
      Cdc6_C; CDC6, C terminal winged helix domain
    2. NM_001190819.2NP_001177748.1  origin recognition complex subunit 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the CDS, resulting in 15 nt fewer than variant 1. The resulting isoform (2) lacks internal 5 aa, as compared to isoform 1.
      Source sequence(s)
      AK303420, DB156841, U43416
      UniProtKB/TrEMBL
      B7Z8H0
      Conserved Domains (4) summary
      cd04719
      Location:44170
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      pfam09079
      Location:773846
      Cdc6_C; CDC6, C terminal
      pfam13191
      Location:499549
      AAA_16; AAA ATPase domain
      cl21455
      Location:525670
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_004153.4NP_004144.2  origin recognition complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_004144.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      U40152, U43416
      Consensus CDS
      CCDS566.1
      UniProtKB/Swiss-Prot
      D3DQ34, Q13415, Q13471, Q5T0F5
      UniProtKB/TrEMBL
      A8K794, Q96F82
      Related
      ENSP00000360623.3, ENST00000371568.8
      Conserved Domains (4) summary
      PRK10811
      Location:362487
      rne; ribonuclease E; Reviewed
      cd04719
      Location:44170
      BAH_Orc1p_animal; BAH, or Bromo Adjacent Homology domain, as present in animal homologs of Saccharomyces cerevisiae Orc1p. Orc1 is part of the Yeast Sir1-origin recognition complex. The Orc1p BAH doman functions in epigenetic silencing. In vertebrates, a similar ORC ...
      PTZ00112
      Location:495743
      PTZ00112; origin recognition complex 1 protein; Provisional
      pfam09079
      Location:778857
      Cdc6_C; CDC6, C terminal winged helix domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52372829..52409503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421674.1XP_047277630.1  origin recognition complex subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ34, Q13415, Q13471, Q5T0F5
      UniProtKB/TrEMBL
      A8K794, Q96F82
    2. XM_047421680.1XP_047277636.1  origin recognition complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A8K794, Q96F82
    3. XM_017001388.3XP_016856877.1  origin recognition complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A8K794, Q96F82
    4. XM_011541527.4XP_011539829.1  origin recognition complex subunit 1 isoform X3

      Conserved Domains (4) summary
      pfam09079
      Location:418491
      Cdc6_C; CDC6, C terminal
      pfam13191
      Location:144194
      AAA_16; AAA ATPase domain
      pfam15091
      Location:34159
      DUF4554; Domain of unknown function (DUF4554)
      cl21455
      Location:170315
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52254294..52290972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336824.1XP_054192799.1  origin recognition complex subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ34, Q13415, Q13471, Q5T0F5
      UniProtKB/TrEMBL
      A8K794, Q96F82
    2. XM_054336826.1XP_054192801.1  origin recognition complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A8K794, Q96F82
    3. XM_054336825.1XP_054192800.1  origin recognition complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A8K794, Q96F82
    4. XM_054336827.1XP_054192802.1  origin recognition complex subunit 1 isoform X3