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    MRPS2 mitochondrial ribosomal protein S2 [ Homo sapiens (human) ]

    Gene ID: 51116, updated on 9-Jun-2024

    Summary

    Official Symbol
    MRPS2provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S2provided by HGNC
    Primary source
    HGNC:HGNC:14495
    See related
    Ensembl:ENSG00000122140 MIM:611971; AllianceGenome:HGNC:14495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S2mt; uS2m; CGI-91; MRP-S2; COXPD36
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in kidney (RPKM 13.4), ovary (RPKM 10.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MRPS2 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135499965..135504673)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147728043..147732751)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138391811..138396519)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20484 Neighboring gene protein phosphatase 1 regulatory subunit 26 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138380833-138381544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138382256-138382966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138382967-138383677 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20485 Neighboring gene piercer of microtubule wall 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:138392753-138393377 Neighboring gene uncharacterized LOC101928525 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:138396029-138396183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138397212-138398185 Neighboring gene NANOG hESC enhancer GRCh37_chr9:138403278-138403841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138406747-138407428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138408918-138409418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138409419-138409919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138416151-138417034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:138418857-138419510 Neighboring gene lipocalin 1 Neighboring gene odorant binding protein 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein uS2m
    Names
    28S ribosomal protein S2, mitochondrial
    mitochondrial small ribosomal subunit protein uS2m

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042313.1 RefSeqGene

      Range
      5052..9041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001371401.1NP_001358330.1  small ribosomal subunit protein uS2m

      Status: REVIEWED

      Source sequence(s)
      AL161452
      Consensus CDS
      CCDS6990.1
      UniProtKB/Swiss-Prot
      Q5T899, Q9BSQ4, Q9Y399
      Related
      ENSP00000360850.1, ENST00000371785.5
      Conserved Domains (1) summary
      cd01425
      Location:84259
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
    2. NM_016034.5NP_057118.1  small ribosomal subunit protein uS2m

      See identical proteins and their annotated locations for NP_057118.1

      Status: REVIEWED

      Source sequence(s)
      BQ065672, BX362434
      Consensus CDS
      CCDS6990.1
      UniProtKB/Swiss-Prot
      Q5T899, Q9BSQ4, Q9Y399
      Related
      ENSP00000241600.5, ENST00000241600.10
      Conserved Domains (1) summary
      cd01425
      Location:84259
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

    RNA

    1. NR_051967.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161452
      Related
      ENST00000485333.6
    2. NR_051968.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161452
      Related
      ENST00000488610.6
    3. NR_051969.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161452
      Related
      ENST00000462948.6
    4. NR_051970.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL161452
      Related
      ENST00000472852.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      135499965..135504673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      147728043..147732751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)