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    PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23262, updated on 7-Apr-2024

    Summary

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    Official Symbol
    PPIP5K2provided by HGNC
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:29035
    See related
    Ensembl:ENSG00000145725 MIM:611648; AllianceGenome:HGNC:29035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VIP2; IP7K2; CFAP160; DFNB100; HISPPD1
    Summary
    This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.5), colon (RPKM 7.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    5q21.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (103120301..103212799)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (103628403..103720883)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (102456005..102548500)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379105 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:102454978-102455479 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:102455480-102455980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:102477431-102477932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22860 Neighboring gene uncharacterized LOC124901037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16211 Neighboring gene macrophage immunometabolism regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PPIP5K2 promotes colorectal carcinoma pathogenesis through facilitating DNA homologous recombination repair. Cao CH, et al. Oncogene, 2021 Dec. PMID 34645979
    2. Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine. An Y, et al. Structure, 2019 Jun 4. PMID 30956131, Free PMC Article
    3. Identification of a functional nuclear translocation sequence in hPPIP5K2. Yong ST, et al. BMC Cell Biol, 2015 Jun 18. PMID 26084399, Free PMC Article
    4. The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Weaver JD, et al. Biosci Rep, 2013 Feb 5. PMID 23240582, Free PMC Article
    5. Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse. Yousaf R, et al. PLoS Genet, 2018 Mar. PMID 29590114, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPIP5K2 promotes colorectal carcinoma pathogenesis through facilitating DNA homologous recombination repair.
      Title: PPIP5K2 promotes colorectal carcinoma pathogenesis through facilitating DNA homologous recombination repair.
    2. PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.
      Title: PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus.
    3. Data suggest that the enzyme-substrate forces are predictive of the various diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) catalytic activities.
      Title: Dynamics of Substrate Processing by PPIP5K2, a Versatile Catalytic Machine.
    4. demonstration that PPIP5K2 has a role in hearing in humans indicates that PP-IP signaling is important to hair cell maintenance and function within inner ear
      Title: Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse.
    5. This study characterized kinetic properties of the bifunctional inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pentakisphosphatekinase/inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate phosphatase activities of full-length diphosphoinositol pentakisphosphate kinase 1 and 2.
      Title: The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.
    6. SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be associated with autism spectrum disorder.
      Title: Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes.
    7. The degree of nuclear localization of hPPIP5K2 was increased when S1006 was rendered non-phosphorylatable by its mutation to Ala.
      Title: Identification of a functional nuclear translocation sequence in hPPIP5K2.
    8. the specificity constants for PPIP5K2 revise upwards by one-to-two orders of magnitude the inherent catalytic activities of this enzyme, and we show its equilibrium point favours 80-90% depletion of InsP/-InsP.
      Title: The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment.
    9. describe the PPIP5K2's conformational dynamics, its unprecedented topological presentation of nucleotide and inositol phosphate, and the charge balance that facilitates partly associative in-line phosphoryl transfer
      Title: Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hearing loss, autosomal recessive 100
    MedGen: C5193087 OMIM: 618422 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21506, FLJ23463, KIAA0433

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diphosphoinositol-pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diphosphoinositol-pentakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diphosphoinositol-pentakisphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol heptakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol heptakisphosphate kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
    Names
    VIP1 homolog 2
    deafness, autosomal recessive 100
    histidine acid phosphatase domain-containing protein 1
    inositol heptaphosphate kinase 2
    insP6 and PP-IP5 kinase 2
    NP_001263206.1
    NP_001268400.1
    NP_001332800.1
    NP_001332801.1
    NP_001332802.1
    NP_001332803.1
    NP_001332804.1
    NP_001332805.1
    NP_001332806.1
    NP_001332807.1
    NP_056031.2
    XP_005277591.1
    XP_005277592.1
    XP_005277593.1
    XP_005277596.1
    XP_005277598.1
    XP_006714639.1
    XP_006714640.1
    XP_011541592.1
    XP_016864762.1
    XP_016864763.1
    XP_047272962.1
    XP_047272963.1
    XP_047272964.1
    XP_047272965.1
    XP_047272966.1
    XP_047272967.1
    XP_047272968.1
    XP_047272969.1
    XP_047272970.1
    XP_054208157.1
    XP_054208158.1
    XP_054208159.1
    XP_054208160.1
    XP_054208161.1
    XP_054208162.1
    XP_054208163.1
    XP_054208164.1
    XP_054208165.1
    XP_054208166.1
    XP_054208167.1
    XP_054208168.1
    XP_054208169.1
    XP_054208170.1
    XP_054208171.1
    XP_054208172.1
    XP_054208173.1
    XP_054208174.1
    XP_054208175.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051568.2 RefSeqGene

      Range
      5002..97500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276277.3 → NP_001263206.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001263206.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks two in-frame exons in the coding region, compared to variant 4. The resulting isoform (1) lacks two internal segments, compared to isoform (3).
      Source sequence(s)
      AB007893, AC011362, AK025159, DB298507
      Consensus CDS
      CCDS64212.1
      UniProtKB/Swiss-Prot
      A1NI53, A6NGS8, O43314, Q8TB50
      UniProtKB/TrEMBL
      B4DGV1
      Related
      ENSP00000351126.3, ENST00000358359.8
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 894
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    2. NM_001281471.3 → NP_001268400.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC011362, AK025159, AK294787, BC024591, DB298507, DC404725
      Consensus CDS
      CCDS75283.1
      UniProtKB/TrEMBL
      A0A087WZV0, B4DGV1
      Related
      ENSP00000482907.1, ENST00000613674.4
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    3. NM_001345871.2 → NP_001332800.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      Consensus CDS
      CCDS93758.1
      UniProtKB/TrEMBL
      A0A8V8TMN4, B4DGV1
      Related
      ENSP00000513912.1, ENST00000698750.1

    4. NM_001345872.2 → NP_001332801.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    5. NM_001345873.2 → NP_001332802.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    6. NM_001345874.2 → NP_001332803.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    7. NM_001345875.2 → NP_001332804.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    8. NM_001345876.2 → NP_001332805.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    9. NM_001345877.2 → NP_001332806.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    10. NM_001345878.2 → NP_001332807.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC008447, AC011362
      UniProtKB/TrEMBL
      B4DGV1

    11. NM_015216.5 → NP_056031.2  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_056031.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three internal exons in the coding region, but maintains the reading frame, compared to variant 4. The resulting isoform (2) lacks two internal segments, compared to isoform 3.
      Source sequence(s)
      AC008447, AC011362
      Consensus CDS
      CCDS34207.1
      UniProtKB/TrEMBL
      B4DGV1
      Related
      ENSP00000313070.8, ENST00000321521.13
      Conserved Domains (2) summary
      pfam00328
      Location:379 → 894
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      cl27318
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      103120301..103212799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005277534.3 → XP_005277591.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    2. XM_005277536.3 → XP_005277593.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    3. XM_006714576.3 → XP_006714639.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    4. XM_005277539.3 → XP_005277596.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    5. XM_047417011.1 → XP_047272967.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

    6. XM_006714577.3 → XP_006714640.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X14

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    7. XM_005277541.3 → XP_005277598.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X17

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    8. XM_047417007.1 → XP_047272963.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

    9. XM_017009274.3 → XP_016864763.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X15

      UniProtKB/TrEMBL
      B4DGV1

    10. XM_005277535.3 → XP_005277592.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

      UniProtKB/TrEMBL
      B4DGV1
      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    11. XM_047417009.1 → XP_047272965.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

    12. XM_047417008.1 → XP_047272964.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

    13. XM_047417012.1 → XP_047272968.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

    14. XM_047417014.1 → XP_047272970.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X18

    15. XM_047417006.1 → XP_047272962.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

    16. XM_047417010.1 → XP_047272966.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

    17. XM_017009273.3 → XP_016864762.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

      UniProtKB/TrEMBL
      B4DGV1

    18. XM_047417013.1 → XP_047272969.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X16

    19. XM_011543290.4 → XP_011541592.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X19

      Conserved Domains (2) summary
      COG0189
      Location:48 → 337
      RimK; Glutathione synthase/RimK-type ligase, ATP-grasp superfamily [Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis]
      pfam00328
      Location:379 → 909
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      103628403..103720883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352182.1 → XP_054208157.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

    2. XM_054352184.1 → XP_054208159.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

    3. XM_054352186.1 → XP_054208161.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

    4. XM_054352189.1 → XP_054208164.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

    5. XM_054352192.1 → XP_054208167.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

    6. XM_054352195.1 → XP_054208170.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X14

    7. XM_054352198.1 → XP_054208173.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X17

    8. XM_054352187.1 → XP_054208162.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

    9. XM_054352196.1 → XP_054208171.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X15

    10. XM_054352183.1 → XP_054208158.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

    11. XM_054352190.1 → XP_054208165.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

    12. XM_054352188.1 → XP_054208163.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

    13. XM_054352193.1 → XP_054208168.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

    14. XM_054352199.1 → XP_054208174.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X18

    15. XM_054352185.1 → XP_054208160.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

    16. XM_054352191.1 → XP_054208166.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

    17. XM_054352194.1 → XP_054208169.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

    18. XM_054352197.1 → XP_054208172.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X16

    19. XM_054352200.1 → XP_054208175.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X19

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43314.3 GenPept UniProtKB/Swiss-Prot:O43314

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