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    PCGF2 polycomb group ring finger 2 [ Homo sapiens (human) ]

    Gene ID: 7703, updated on 9-Jun-2024

    Summary

    Official Symbol
    PCGF2provided by HGNC
    Official Full Name
    polycomb group ring finger 2provided by HGNC
    Primary source
    HGNC:HGNC:12929
    See related
    Ensembl:ENSG00000277258 MIM:600346; AllianceGenome:HGNC:12929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPFS; MEL-18; RNF110; ZNF144
    Summary
    The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PCGF2 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38733898..38749792, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39596983..39611419, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36890151..36904589, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MLLT6, PHD finger containing Neighboring gene uncharacterized LOC105371762 Neighboring gene microRNA 4726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36881911-36882602 Neighboring gene control region 19 heart enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36887390-36887927 Neighboring gene RNA, 5S ribosomal pseudogene 440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36891176-36891703 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36898365-36899265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36901628-36902393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36902394-36903158 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36904187-36904722 Neighboring gene uncharacterized LOC100287808 Neighboring gene tRNA-Asn (anticodon GTT) 2-5 Neighboring gene RNA, U6 small nuclear 866, pseudogene Neighboring gene proteasome 20S subunit beta 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10545

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sex chromatin IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    polycomb group RING finger protein 2
    Names
    DNA-binding protein Mel-18
    ring finger protein 110
    zinc finger protein 144

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369614.1NP_001356543.1  polycomb group RING finger protein 2

      Status: REVIEWED

      Source sequence(s)
      AC006449
      Consensus CDS
      CCDS32638.1
      UniProtKB/Swiss-Prot
      A6NGD8, P35227
      Conserved Domains (3) summary
      PLN02217
      Location:236328
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      cd16736
      Location:1265
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
    2. NM_001369615.1NP_001356544.1  polycomb group RING finger protein 2

      Status: REVIEWED

      Source sequence(s)
      AC006449, D13969
      Consensus CDS
      CCDS32638.1
      UniProtKB/Swiss-Prot
      A6NGD8, P35227
      Related
      ENSP00000478970.1, ENST00000611883.4
      Conserved Domains (3) summary
      PLN02217
      Location:236328
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      cd16736
      Location:1265
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
    3. NM_007144.3NP_009075.1  polycomb group RING finger protein 2

      See identical proteins and their annotated locations for NP_009075.1

      Status: REVIEWED

      Source sequence(s)
      AC006449
      Consensus CDS
      CCDS32638.1
      UniProtKB/Swiss-Prot
      A6NGD8, P35227
      Related
      ENSP00000482815.1, ENST00000620225.5
      Conserved Domains (3) summary
      PLN02217
      Location:236328
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      cd16736
      Location:1265
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      38733898..38749792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436660.1XP_047292616.1  polycomb group RING finger protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A6NGD8, P35227
    2. XM_017025016.2XP_016880505.1  polycomb group RING finger protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A6NGD8, P35227
      Conserved Domains (3) summary
      PLN02217
      Location:236328
      PLN02217; probable pectinesterase/pectinesterase inhibitor
      cd16736
      Location:1265
      RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
      cd17164
      Location:130228
      RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
    3. XM_047436661.1XP_047292617.1  polycomb group RING finger protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A6NGD8, P35227

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      2769217..2783655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329331.1XP_054185306.1  polycomb group RING finger protein 2 isoform X1

      UniProtKB/Swiss-Prot
      A6NGD8, P35227

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      39596983..39611419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)