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    MN1 MN1 proto-oncogene, transcriptional regulator [ Homo sapiens (human) ]

    Gene ID: 4330, updated on 7-Apr-2024

    Summary

    Official Symbol
    MN1provided by HGNC
    Official Full Name
    MN1 proto-oncogene, transcriptional regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:7180
    See related
    Ensembl:ENSG00000169184 MIM:156100; AllianceGenome:HGNC:7180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGCR; MGCR1; CEBALID; MGCR1-PEN; dJ353E16.2
    Summary
    Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 2.3), esophagus (RPKM 2.2) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MN1 in Genome Data Viewer
    Location:
    22q12.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (27748277..27801756, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (28209592..28263071, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (28144265..28197744, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372981 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27937522-27938022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27938023-27938523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27957435-27957934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27969749-27970322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27971900-27972400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27972401-27972901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27987245-27987744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999453-27999970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27999971-28000486 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28026616-28027234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28029867-28030460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28033379-28033879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034092-28034896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28034897-28035700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28037955-28038888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28050431-28050930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28063419-28063918 Neighboring gene Sharpr-MPRA regulatory regions 2672 and 6919 Neighboring gene uncharacterized LOC124905098 Neighboring gene cytoplasmic mesoderm regulator Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:28113736-28114935 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28138905-28139406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:28138404-28138904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28142924-28143424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28145441-28146311 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28153780-28154462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28161389-28161890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28161891-28162390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28175917-28176543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28181385-28181912 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr22:28186882-28187858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28194718-28195264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28195265-28195810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28200153-28200717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28200718-28201281 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28205997-28206518 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28206519-28207040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28217251-28217750 Neighboring gene uncharacterized LOC107985529 Neighboring gene VISTA enhancer hs1271 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:28246273-28246791 Neighboring gene phosphatidylinositol transfer protein beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28314444-28315429

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Electronic medical records and genomics (eMERGE) network exploration in cataract: Several new potential susceptibility loci.
    EBI GWAS Catalog
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcriptional activator MN1
    Names
    meningioma (disrupted in balanced translocation) 1
    meningioma (translocation balanced)
    meningioma chromosome region 1
    probable tumor suppressor protein MN1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023258.1 RefSeqGene

      Range
      4743..58222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002430.3NP_002421.3  transcriptional activator MN1

      See identical proteins and their annotated locations for NP_002421.3

      Status: REVIEWED

      Source sequence(s)
      AL031591, X82209
      Consensus CDS
      CCDS42998.1
      UniProtKB/Swiss-Prot
      A9Z1V9, Q10571
      UniProtKB/TrEMBL
      A5HML1
      Related
      ENSP00000304956.4, ENST00000302326.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      27748277..27801756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      28209592..28263071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)