U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    TRAPPC12 trafficking protein particle complex subunit 12 [ Homo sapiens (human) ]

    Gene ID: 51112, updated on 3-Apr-2024

    Summary

    Official Symbol
    TRAPPC12provided by HGNC
    Official Full Name
    trafficking protein particle complex subunit 12provided by HGNC
    Primary source
    HGNC:HGNC:24284
    See related
    Ensembl:ENSG00000171853 MIM:614139; AllianceGenome:HGNC:24284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PEBAS; TTC15; CGI-87; TTC-15
    Summary
    Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of TRAPP complex. Colocalizes with endoplasmic reticulum-Golgi intermediate compartment and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 2.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2p25.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (3379694..3479565)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (3401815..3501615)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (3383465..3483336)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3172751-3173696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3182069-3182826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3183585-3184342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3184343-3185098 Neighboring gene Sharpr-MPRA regulatory region 8446 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:3202367-3202905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3204190-3204746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15224 Neighboring gene EARP complex and GARP complex interacting protein 1 Neighboring gene MPRA-validated peak3584 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:3237853-3239052 Neighboring gene Sharpr-MPRA regulatory region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15226 Neighboring gene VISTA enhancer hs1385 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3284251-3284751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3289510-3290088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3290089-3290666 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:3310431-3310601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3323251-3323862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3326607-3327134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3327135-3327662 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:3358809-3358982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15227 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3381914-3382430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3382431-3382947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11109 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3402817-3403742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3403743-3404668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3404669-3405592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3416341-3416841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3415840-3416340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3434408-3434908 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:3437307-3437557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3463593-3464106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3464459-3465326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3475415-3475916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:3475917-3476416 Neighboring gene TRAPPC12 antisense RNA 1 Neighboring gene uncharacterized LOC112268321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11111 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:3522968-3523489 Neighboring gene acireductone dioxygenase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    Early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome
    MedGen: C5567229 OMIM: 617669 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of trafficking protein particle complex 12 (TRAPPC12) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ36862, FLJ44560

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TRAPP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with endoplasmic reticulum-Golgi intermediate compartment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with perinuclear region of cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    trafficking protein particle complex subunit 12
    Names
    TPR repeat protein 15
    tetratricopeptide repeat domain 15
    tetratricopeptide repeat protein 15
    trafficking of membranes and mitosis
    trafficking protein particle complex 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321102.2NP_001308031.1  trafficking protein particle complex subunit 12

      Status: VALIDATED

      Source sequence(s)
      AC114810, AK098327
      Consensus CDS
      CCDS1652.1
      UniProtKB/Swiss-Prot
      B3KV01, D6W4Y2, Q8WVT3, Q8WVW1, Q9Y395
      UniProtKB/TrEMBL
      Q8N9N0
      Related
      ENSP00000371544.2, ENST00000382110.6
      Conserved Domains (4) summary
      sd00006
      Location:546573
      TPR; TPR repeat [structural motif]
      pfam11035
      Location:61134
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
      pfam13414
      Location:622685
      TPR_11; TPR repeat
      pfam13424
      Location:581652
      TPR_12; Tetratricopeptide repeat
    2. NM_016030.6NP_057114.5  trafficking protein particle complex subunit 12

      See identical proteins and their annotated locations for NP_057114.5

      Status: VALIDATED

      Source sequence(s)
      AF151845, BC014164, BC017475, DA031172
      Consensus CDS
      CCDS1652.1
      UniProtKB/Swiss-Prot
      B3KV01, D6W4Y2, Q8WVT3, Q8WVW1, Q9Y395
      UniProtKB/TrEMBL
      Q8N9N0
      Related
      ENSP00000324318.5, ENST00000324266.10
      Conserved Domains (4) summary
      sd00006
      Location:546573
      TPR; TPR repeat [structural motif]
      pfam11035
      Location:61134
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
      pfam13414
      Location:622685
      TPR_11; TPR repeat
      pfam13424
      Location:581652
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      3379694..3479565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510350.3XP_011508652.1  trafficking protein particle complex subunit 12 isoform X1

      UniProtKB/TrEMBL
      Q8N9N0
      Conserved Domains (4) summary
      sd00006
      Location:508535
      TPR; TPR repeat [structural motif]
      pfam11035
      Location:61134
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
      pfam13414
      Location:584647
      TPR_11; TPR repeat
      pfam13424
      Location:543614
      TPR_12; Tetratricopeptide repeat
    2. XM_047444637.1XP_047300593.1  trafficking protein particle complex subunit 12 isoform X1

    3. XM_011510352.3XP_011508654.1  trafficking protein particle complex subunit 12 isoform X2

      Conserved Domains (1) summary
      pfam11035
      Location:61134
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    4. XM_047444639.1XP_047300595.1  trafficking protein particle complex subunit 12 isoform X3

    5. XM_047444638.1XP_047300594.1  trafficking protein particle complex subunit 12 isoform X2

    6. XM_011510353.3XP_011508655.1  trafficking protein particle complex subunit 12 isoform X4

      Conserved Domains (1) summary
      pfam11035
      Location:61134
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    7. XM_011510354.3XP_011508656.1  trafficking protein particle complex subunit 12 isoform X5

      Conserved Domains (1) summary
      pfam11035
      Location:61134
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    8. XM_011510355.3XP_011508657.1  trafficking protein particle complex subunit 12 isoform X6

      UniProtKB/TrEMBL
      Q53QD4
      Conserved Domains (4) summary
      TIGR02795
      Location:234293
      tol_pal_ybgF; tol-pal system protein YbgF
      sd00006
      Location:231258
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:307370
      TPR_11; TPR repeat
      pfam13424
      Location:266337
      TPR_12; Tetratricopeptide repeat
    9. XM_011510356.2XP_011508658.1  trafficking protein particle complex subunit 12 isoform X7

      See identical proteins and their annotated locations for XP_011508658.1

      UniProtKB/TrEMBL
      A0A0J9YXQ9, Q53QD4
      Conserved Domains (3) summary
      sd00006
      Location:190217
      TPR; TPR repeat [structural motif]
      cl26002
      Location:199379
      TPR_11; TPR repeat
      cl26250
      Location:193252
      TPR_6; Tetratricopeptide repeat

    RNA

    1. XR_426956.4 RNA Sequence

    2. XR_007076381.1 RNA Sequence

    3. XR_001738761.2 RNA Sequence

    4. XR_007076382.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187522.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      9876..89035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      3401815..3501615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342395.1XP_054198370.1  trafficking protein particle complex subunit 12 isoform X1

    2. XM_054342396.1XP_054198371.1  trafficking protein particle complex subunit 12 isoform X1

    3. XM_054342397.1XP_054198372.1  trafficking protein particle complex subunit 12 isoform X2

    4. XM_054342399.1XP_054198374.1  trafficking protein particle complex subunit 12 isoform X3

    5. XM_054342398.1XP_054198373.1  trafficking protein particle complex subunit 12 isoform X2

    6. XM_054342400.1XP_054198375.1  trafficking protein particle complex subunit 12 isoform X4

    7. XM_054342401.1XP_054198376.1  trafficking protein particle complex subunit 12 isoform X5

    8. XM_054342403.1XP_054198378.1  trafficking protein particle complex subunit 12 isoform X7

      UniProtKB/TrEMBL
      A0A0J9YXQ9
    9. XM_054342402.1XP_054198377.1  trafficking protein particle complex subunit 12 isoform X6

    RNA

    1. XR_008486387.1 RNA Sequence

    2. XR_008486386.1 RNA Sequence

    3. XR_008486385.1 RNA Sequence

    4. XR_008486388.1 RNA Sequence