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    H4C3 H4 clustered histone 3 [ Homo sapiens (human) ]

    Gene ID: 8364, updated on 5-Mar-2024


    Official Symbol
    H4C3provided by HGNC
    Official Full Name
    H4 clustered histone 3provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000197061 MIM:602827; AllianceGenome:HGNC:4787
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H4/g; H4C1; H4C2; H4C4; H4C5; H4C6; H4C8; H4C9; H4FG; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4C; TEVANED1; TEBIVANED1; dJ221C16.1
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
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    Genomic context

    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26103933..26104337)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25972081..25972485)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26104161..26104565)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24187 Neighboring gene H1.2 linker histone, cluster member Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26066841-26067340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26075238-26075738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26075739-26076239 Neighboring gene HFE antisense RNA 1 Neighboring gene homeostatic iron regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24188 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:26103833-26104523 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H2B clustered histone 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26121574-26122260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26122261-26122945 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:26123079-26124278

    Genomic regions, transcripts, and products


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?


    Associated conditions

    Description Tests
    Tessadori-van Haaften neurodevelopmental syndrome 1
    MedGen: C5676922 OMIM: 619758 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed
    nucleocapsid gag HIV-1 NC downregulates histone cluster 1, H4C in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    enables DNA binding TAS
    Traceable Author Statement
    more info
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    enables structural constituent of chromatin IDA
    Inferred from Direct Assay
    more info

    General protein information

    Preferred Names
    histone H4
    H4 histone family, member G
    histone 1, H4c
    histone cluster 1 H4 family member c
    histone cluster 1, H4c

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003542.4NP_003533.1  histone H4

      See identical proteins and their annotated locations for NP_003533.1

      Status: REVIEWED

      Source sequence(s)
      Consensus CDS
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      ENSP00000367034.3, ENST00000377803.4
      Conserved Domains (1) summary
      PLN00035; histone H4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly


    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0


    1. NC_060930.1 Alternate T2T-CHM13v2.0

      GenBank, FASTA, Sequence Viewer (Graphics)