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    HINT1 histidine triad nucleotide binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 3094, updated on 5-May-2024

    Summary

    Official Symbol
    HINT1provided by HGNC
    Official Full Name
    histidine triad nucleotide binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:4912
    See related
    Ensembl:ENSG00000169567 MIM:601314; AllianceGenome:HGNC:4912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HINT; NMAN; PKCI-1; PRKCNH1
    Summary
    This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in colon (RPKM 85.2), liver (RPKM 83.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HINT1 in Genome Data Viewer
    Location:
    5q23.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (131159027..131165256, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (131678018..131684247, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (130494720..130500949, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SURP and G-patch domain containing 1 pseudogene Neighboring gene uncharacterized LOC105379172 Neighboring gene NANOG hESC enhancer GRCh37_chr5:130400159-130400717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:130447686-130448186 Neighboring gene Sharpr-MPRA regulatory region 1831 Neighboring gene H3K27ac hESC enhancers GRCh37_chr5:130499678-130500338 and GRCh37_chr5:130500339-130500998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16303 Neighboring gene LYR motif containing 7 Neighboring gene uncharacterized LOC124901061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23043 Neighboring gene CDC42 small effector 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of histidine triad nucleotide binding protein 1 (HINT1) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30414, FLJ32340

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adenosine 5'-monophosphoramidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables adenosine 5'-monophosphoramidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables deSUMOylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular exosome HDA PubMed 
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    adenosine 5'-monophosphoramidase HINT1
    Names
    adenosine 5'-monophosphoramidase
    desumoylating isopeptidase HINT1
    epididymis secretory sperm binding protein
    protein kinase C inhibitor 1
    protein kinase C-interacting protein 1
    NP_005331.1
    XP_047273089.1
    XP_054208456.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032998.1 RefSeqGene

      Range
      5093..11322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005340.7NP_005331.1  adenosine 5'-monophosphoramidase HINT1

      See identical proteins and their annotated locations for NP_005331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AA076103, AC004650, BC007090
      Consensus CDS
      CCDS4147.1
      UniProtKB/Swiss-Prot
      P49773, Q9H5W8
      UniProtKB/TrEMBL
      A0A384NPU2
      Related
      ENSP00000304229.5, ENST00000304043.10
      Conserved Domains (1) summary
      cd01276
      Location:16118
      PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...

    RNA

    1. NR_024610.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA076103, AC004650, BC028300
    2. NR_024611.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because there is uncertainty about the protein-coding capacity of the transcript.
      Source sequence(s)
      AA076103, AC004650, CK002748, CN290239
    3. NR_073488.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' exon and includes two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA076103, AC004650, BF967059, CD639104, CN290239
    4. NR_134494.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004650, BC028300, BG393782, CN290233
    5. NR_134495.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC004650, BF970603, BG708765, CN290233

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      131159027..131165256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417133.1XP_047273089.1  adenosine 5'-monophosphoramidase HINT1 isoform X1

      UniProtKB/TrEMBL
      D6RD60
      Related
      ENSP00000502370.1, ENST00000675491.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      131678018..131684247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352481.1XP_054208456.1  adenosine 5'-monophosphoramidase HINT1 isoform X1

      UniProtKB/TrEMBL
      D6RD60