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    PGM2L1 phosphoglucomutase 2 like 1 [ Homo sapiens (human) ]

    Gene ID: 283209, updated on 17-Jun-2024

    Summary

    Official Symbol
    PGM2L1provided by HGNC
    Official Full Name
    phosphoglucomutase 2 like 1provided by HGNC
    Primary source
    HGNC:HGNC:20898
    See related
    Ensembl:ENSG00000165434 MIM:611610; AllianceGenome:HGNC:20898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM32A; PMMLP; NEDHFS
    Summary
    Enables glucose-1,6-bisphosphate synthase activity. Predicted to be involved in glucose metabolic process and phosphorylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 28.2), endometrium (RPKM 3.0) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PGM2L1 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (74330316..74398433, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (74259645..74327847, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74041361..74109478, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase methylesterase 1 Neighboring gene small nucleolar RNA SNORA7 Neighboring gene prolyl 4-hydroxylase subunit alpha 3 Neighboring gene P4HA3 antisense RNA 1 Neighboring gene uncharacterized LOC112268078 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74107127-74107628 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74107629-74108128 Neighboring gene H3K27ac hESC enhancers GRCh37_chr11:74109220-74109841 and GRCh37_chr11:74109842-74110462 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:74123584-74124783 Neighboring gene microRNA 548al Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32029, FLJ33458, MGC71501

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glucose-1,6-bisphosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucose-1,6-bisphosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucose-1,6-bisphosphate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    glucose 1,6-bisphosphate synthase
    NP_775853.2
    XP_011543255.1
    XP_054224455.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173582.6NP_775853.2  glucose 1,6-bisphosphate synthase

      See identical proteins and their annotated locations for NP_775853.2

      Status: VALIDATED

      Source sequence(s)
      AP001085
      Consensus CDS
      CCDS8231.1
      UniProtKB/Swiss-Prot
      Q6PCE3, Q96MQ7, Q9UIK3
      Related
      ENSP00000298198.4, ENST00000298198.5
      Conserved Domains (2) summary
      cd05799
      Location:64607
      PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
      PTZ00150
      Location:24621
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      74330316..74398433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544953.4XP_011543255.1  glucose 1,6-bisphosphate synthase isoform X1

      Conserved Domains (2) summary
      cd05799
      Location:85628
      PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
      PTZ00150
      Location:24642
      PTZ00150; phosphoglucomutase-2-like protein; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      74259645..74327847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368480.1XP_054224455.1  glucose 1,6-bisphosphate synthase isoform X1