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    ROBO1 roundabout guidance receptor 1 [ Homo sapiens (human) ]

    Gene ID: 6091, updated on 7-Apr-2024

    Summary

    Official Symbol
    ROBO1provided by HGNC
    Official Full Name
    roundabout guidance receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:10249
    See related
    Ensembl:ENSG00000169855 MIM:602430; AllianceGenome:HGNC:10249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NORS; NYS8; SAX3; CPHD8; DUTT1
    Summary
    Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in brain (RPKM 11.9), skin (RPKM 9.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ROBO1 in Genome Data Viewer
    Location:
    3p12.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (78597239..79767998, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (78652524..79823991, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (78646389..79817148, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:78315096-78316295 Neighboring gene RN7SK pseudogene 61 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:78371863-78372653 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:78392873-78394072 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:78402403-78402950 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:78630276-78631137 Neighboring gene mitochondrial ribosomal protein S17 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 7147 Neighboring gene Sharpr-MPRA regulatory region 6803 Neighboring gene ribosomal protein S12 pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr3:79006574-79007156 Neighboring gene VISTA enhancer hs1475 Neighboring gene RNA, 7SL, cytoplasmic 751, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:79174827-79175326 Neighboring gene NANOG hESC enhancer GRCh37_chr3:79209960-79210461 Neighboring gene uncharacterized LOC101927374 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:79667239-79668438 Neighboring gene microRNA 3923 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:79914289-79914466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:79986556-79987112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:80101631-80102130 Neighboring gene high mobility group box 1 pseudogene 38 Neighboring gene oxysterol binding protein like 9 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurooculorenal syndrome
    MedGen: C5830377 OMIM: 620305 GeneReviews: Not available
    not available
    Nystagmus, congenital, autosomal recessive
    MedGen: C3151571 OMIM: 257400 GeneReviews: Not available
    not available
    Pituitary hormone deficiency, combined or isolated, 8
    MedGen: C5830375 OMIM: 620303 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-09-25)

    ClinGen Genome Curation Page
    Haploinsufficency

    No evidence available (Last evaluated 2018-09-25)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    EBI GWAS Catalog
    Genome-wide association study of liver enzymes in korean children.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The N-terminal leucine-rich repeat fragment of Slit2 inhibits HIV-1 gp120-induced ROBO1-actin association PubMed
    env Inhibition of M-tropic HIV-1 gp120-induced transendothelial migration by SLIT2N involves SLIT2N-mediated enhancement of co-localization of Robo1 with WASp and LSP1 in immature monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21882, MGC131599, MGC133277

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables LRR domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables axon guidance receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Roundabout signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in aorta development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in aortic valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon midline choice point recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemorepulsion involved in postnatal olfactory bulb interneuron migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heart induction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chemokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of negative chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pulmonary valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ventricular septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    roundabout homolog 1
    Names
    deleted in U twenty twenty
    roundabout, axon guidance receptor, homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011729.1 RefSeqGene

      Range
      4912..1175671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145845.2NP_001139317.1  roundabout homolog 1 isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, lacks an alternate in-frame exon in the central coding region, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and differs at three internal regions, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.
      Source sequence(s)
      AC016946, AC055731, AC106720, AC108719, AK025535, BC115022, BP228659
      Consensus CDS
      CCDS54610.1
      UniProtKB/TrEMBL
      Q2M1J3
      Related
      ENSP00000417992.1, ENST00000467549.5
      Conserved Domains (7) summary
      cd00063
      Location:525611
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:742828
      fn3; Fibronectin type III domain
      cd05724
      Location:134219
      IgI_2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05725
      Location:226308
      IgI_3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd05726
      Location:316413
      IgI_4_Robo; Fourth immunoglobulin (Ig)-like domain in Robo (roundabout) receptors; member of the I-set of Ig superfamily (IgSF) domains
      cd07693
      Location:29127
      IgC_1_Robo; First immunoglobulin (Ig)-like constant domain in Robo (roundabout) receptors, and similar domains
      cd20952
      Location:420506
      IgI_5_Robo; Fifth Ig-like domain of Roundabout (Robo) homolog 1/2, and similar domains; a member of the I-set of IgSF domains
    2. NM_002941.4NP_002932.1  roundabout homolog 1 isoform a precursor

      See identical proteins and their annotated locations for NP_002932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC125624, AF040990, AK025535, DR003097
      Consensus CDS
      CCDS54611.1
      UniProtKB/Swiss-Prot
      B2RXI1, D3DU36, E9PD49, Q1RMC7, Q7Z300, Q9BUS7, Q9Y6N7
      UniProtKB/TrEMBL
      Q2M1J3
      Related
      ENSP00000420321.1, ENST00000464233.6
      Conserved Domains (8) summary
      cd05724
      Location:174258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:365454
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:561647
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:778864
      fn3; Fibronectin type III domain
      cl11960
      Location:459533
      Ig; Immunoglobulin domain
    3. NM_133631.4NP_598334.2  roundabout homolog 1 isoform b precursor

      See identical proteins and their annotated locations for NP_598334.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a distinct translation start site, includes an alternate in-frame exon in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus, compared to isoform a. The 5' UTR of this variant contains a 55 aa uORF with a strong Kozak signal that may inhibit translation of this protein.
      Source sequence(s)
      AC016946, BC029676, BC115020, BC157861, BP228659
      Consensus CDS
      CCDS46872.2
      UniProtKB/TrEMBL
      Q2M1J3
      Related
      ENSP00000420637.1, ENST00000495273.5
      Conserved Domains (8) summary
      cd05724
      Location:135219
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:240308
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:329418
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:28127
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:525611
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:223308
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:742828
      fn3; Fibronectin type III domain
      cl11960
      Location:423497
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      78597239..79767998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006982.2XP_016862471.1  roundabout homolog 1 isoform X4

      UniProtKB/TrEMBL
      Q2M1J3
    2. XM_047448664.1XP_047304620.1  roundabout homolog 1 isoform X12

    3. XM_047448661.1XP_047304617.1  roundabout homolog 1 isoform X3

    4. XM_017006984.1XP_016862473.1  roundabout homolog 1 isoform X10

      UniProtKB/TrEMBL
      Q2M1J3
    5. XM_011533980.1XP_011532282.1  roundabout homolog 1 isoform X11

      UniProtKB/TrEMBL
      Q2M1J3
      Conserved Domains (8) summary
      cd05724
      Location:174258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:368457
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:564650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:781867
      fn3; Fibronectin type III domain
      cl11960
      Location:462536
      Ig; Immunoglobulin domain
    6. XM_011533978.1XP_011532280.1  roundabout homolog 1 isoform X2

      UniProtKB/TrEMBL
      Q2M1J3
      Conserved Domains (8) summary
      cd05724
      Location:174258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:368457
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:564650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:781867
      fn3; Fibronectin type III domain
      cl11960
      Location:462536
      Ig; Immunoglobulin domain
    7. XM_011533979.1XP_011532281.1  roundabout homolog 1 isoform X9

      UniProtKB/TrEMBL
      Q2M1J3
      Conserved Domains (8) summary
      cd05724
      Location:174258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:368457
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:564650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:781867
      fn3; Fibronectin type III domain
      cl11960
      Location:462536
      Ig; Immunoglobulin domain
    8. XM_011533976.1XP_011532278.1  roundabout homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011532278.1

      UniProtKB/TrEMBL
      Q2M1J3
      Conserved Domains (8) summary
      cd05724
      Location:174258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:368457
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:564650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:781867
      fn3; Fibronectin type III domain
      cl11960
      Location:462536
      Ig; Immunoglobulin domain
    9. XM_011533977.3XP_011532279.1  roundabout homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011532279.1

      UniProtKB/TrEMBL
      Q2M1J3
      Conserved Domains (8) summary
      cd05724
      Location:174258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:368457
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:564650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:781867
      fn3; Fibronectin type III domain
      cl11960
      Location:462536
      Ig; Immunoglobulin domain
    10. XM_047448665.1XP_047304621.1  roundabout homolog 1 isoform X13

    11. XM_047448663.1XP_047304619.1  roundabout homolog 1 isoform X8

    12. XM_017006983.3XP_016862472.1  roundabout homolog 1 isoform X7

      UniProtKB/TrEMBL
      Q2M1J3
      Related
      ENSP00000406043.3, ENST00000436010.6
      Conserved Domains (8) summary
      cd05724
      Location:135219
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:240308
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:326415
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:28127
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:522608
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:223308
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:739825
      fn3; Fibronectin type III domain
      cl11960
      Location:420494
      Ig; Immunoglobulin domain
    13. XM_006713277.4XP_006713340.1  roundabout homolog 1 isoform X5

      UniProtKB/TrEMBL
      Q2M1J3
      Conserved Domains (8) summary
      cd05724
      Location:135219
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:240308
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:329418
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:28127
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:525611
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:223308
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:742828
      fn3; Fibronectin type III domain
      cl11960
      Location:423497
      Ig; Immunoglobulin domain
    14. XM_017006985.2XP_016862474.1  roundabout homolog 1 isoform X14

      UniProtKB/TrEMBL
      A0A0A0MSX4
    15. XM_047448662.1XP_047304618.1  roundabout homolog 1 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      78652524..79823991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347447.1XP_054203422.1  roundabout homolog 1 isoform X4

    2. XM_054347455.1XP_054203430.1  roundabout homolog 1 isoform X12

    3. XM_054347446.1XP_054203421.1  roundabout homolog 1 isoform X3

    4. XM_054347453.1XP_054203428.1  roundabout homolog 1 isoform X10

    5. XM_054347454.1XP_054203429.1  roundabout homolog 1 isoform X11

    6. XM_054347445.1XP_054203420.1  roundabout homolog 1 isoform X2

    7. XM_054347452.1XP_054203427.1  roundabout homolog 1 isoform X9

    8. XM_054347443.1XP_054203418.1  roundabout homolog 1 isoform X1

    9. XM_054347444.1XP_054203419.1  roundabout homolog 1 isoform X1

    10. XM_054347456.1XP_054203431.1  roundabout homolog 1 isoform X13

    11. XM_054347451.1XP_054203426.1  roundabout homolog 1 isoform X8

    12. XM_054347450.1XP_054203425.1  roundabout homolog 1 isoform X7

    13. XM_054347448.1XP_054203423.1  roundabout homolog 1 isoform X5

    14. XM_054347449.1XP_054203424.1  roundabout homolog 1 isoform X6