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    TPR translocated promoter region, nuclear basket protein [ Homo sapiens (human) ]

    Gene ID: 7175, updated on 5-May-2024

    Summary

    Official Symbol
    TPRprovided by HGNC
    Official Full Name
    translocated promoter region, nuclear basket proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12017
    See related
    Ensembl:ENSG00000047410 MIM:189940; AllianceGenome:HGNC:12017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRT79
    Summary
    This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TPR in Genome Data Viewer
    Location:
    1q31.1
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (186311652..186375253, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (185666310..185729984, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186280784..186344385, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hemicentin 1 Neighboring gene uncharacterized LOC105371654 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:186156636-186157835 Neighboring gene MPRA-validated peak514 silencer Neighboring gene uncharacterized LOC124904471 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:186214031-186214197 Neighboring gene RNA, U6 small nuclear 1240, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:186312648-186313847 Neighboring gene MPRA-validated peak515 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:186323778-186324977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2248 Neighboring gene proteoglycan 4 Neighboring gene odr-4 GPCR localization factor homolog Neighboring gene PDC antisense RNA 1 Neighboring gene phosducin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication requires PSIP1 (LEDGF/p75) and TPR to maintain chromatin structure amenable to integration as shown through shRNA treatment PubMed
    HIV-1 requires NUP153 and TPR for infectivity as shown by shRNA knockdown experiments utilizing HeLa-derived P4-CCR5 cells and jurkat T cells PubMed
    Knockdown of translocated promoter region (to activated MET oncogene) (TPR) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated nucleoprotein TPR is incorporated into HIV-1 Gag virus-like particles PubMed
    Tat tat Depletion of translocated promoter region, nuclear basket protein (TPR) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interferon-alpha ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA export from nucleus in response to heat stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of RNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of RNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in nuclear matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in nuclear pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear pore organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to epidermal growth factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear pore nuclear basket IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleoprotein TPR
    Names
    NPC-associated intranuclear protein
    megator
    nuclear pore complex-associated protein TPR
    translocated promoter region (to activated MET oncogene)
    translocated promoter region protein
    tumor potentiating region

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023284.1 RefSeqGene

      Range
      5073..68674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003292.3NP_003283.2  nucleoprotein TPR

      See identical proteins and their annotated locations for NP_003283.2

      Status: REVIEWED

      Source sequence(s)
      AA688415, AL133553, AL596220, U69668, X66397
      Consensus CDS
      CCDS41446.1
      UniProtKB/Swiss-Prot
      P12270, Q15624, Q5SWY0, Q99968
      Related
      ENSP00000356448.3, ENST00000367478.9
      Conserved Domains (5) summary
      COG1196
      Location:53796
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR04527
      Location:9641050
      mycoplas_twoTM; two transmembrane protein
      pfam00038
      Location:7651087
      Filament; Intermediate filament protein
      pfam07851
      Location:14331509
      TMPIT; TMPIT-like protein
      pfam07926
      Location:10381166
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      186311652..186375253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      185666310..185729984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)