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    WNT10A Wnt family member 10A [ Homo sapiens (human) ]

    Gene ID: 80326, updated on 12-Feb-2024

    Summary

    Official Symbol
    WNT10Aprovided by HGNC
    Official Full Name
    Wnt family member 10Aprovided by HGNC
    Primary source
    HGNC:HGNC:13829
    See related
    Ensembl:ENSG00000135925 MIM:606268; AllianceGenome:HGNC:13829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OODD; SSPS; ECTD16; STHAG4
    Summary
    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in skin (RPKM 3.0), placenta (RPKM 1.8) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WNT10A in Genome Data Viewer
    Location:
    2q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218874116..218893928)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219362519..219382296)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219745574..219758650)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:219687585-219688784 Neighboring gene microRNA 9500 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3 Neighboring gene ribosomal protein L23a pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12327 Neighboring gene Wnt family member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219736377-219737323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17131 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:219757282-219757864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17134 Neighboring gene uncharacterized LOC105373882 Neighboring gene Sharpr-MPRA regulatory region 8081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12337 Neighboring gene long intergenic non-protein coding RNA 1494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17136 Neighboring gene uncharacterized LOC124906119 Neighboring gene RNA, U6 small nuclear 642, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Odonto-onycho-dermal dysplasia
    MedGen: C0796093 OMIM: 257980 GeneReviews: Not available
    Compare labs
    SchC6pf-Schulz-Passarge syndrome
    MedGen: C1857069 OMIM: 224750 GeneReviews: Not available
    Compare labs
    Tooth agenesis, selective, 4
    MedGen: C1835492 OMIM: 150400 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Common variants in the trichohyalin gene are associated with straight hair in Europeans.
    EBI GWAS Catalog
    Web-based, participant-driven studies yield novel genetic associations for common traits.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14301

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sebaceous gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tongue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein Wnt-10a
    Names
    wingless-type MMTV integration site family, member 10A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012179.1 RefSeqGene

      Range
      5320..18396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_025216.3NP_079492.2  protein Wnt-10a precursor

      See identical proteins and their annotated locations for NP_079492.2

      Status: REVIEWED

      Source sequence(s)
      AC073128
      Consensus CDS
      CCDS2426.1
      UniProtKB/Swiss-Prot
      Q53S44, Q96TA7, Q9GZT5, Q9H7S8
      UniProtKB/TrEMBL
      A0A2H4GYZ1, A0A2K8FR47
      Related
      ENSP00000258411.3, ENST00000258411.8
      Conserved Domains (1) summary
      cl38924
      Location:58417
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218874116..218893928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511929.3XP_011510231.1  protein Wnt-10a isoform X1

      UniProtKB/TrEMBL
      A0A2H4GYZ1
      Conserved Domains (1) summary
      pfam00110
      Location:35385
      wnt; wnt family
    2. XM_011511930.2XP_011510232.1  protein Wnt-10a isoform X2

      Conserved Domains (1) summary
      cl19568
      Location:67127
      wnt; wnt family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      219362519..219382296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344058.1XP_054200033.1  protein Wnt-10a isoform X1

      UniProtKB/TrEMBL
      A0A2H4GYZ1
    2. XM_054344057.1XP_054200032.1  protein Wnt-10a isoform X2