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    KRT17 keratin 17 [ Homo sapiens (human) ]

    Gene ID: 3872, updated on 6-May-2024

    Summary

    Official Symbol
    KRT17provided by HGNC
    Official Full Name
    keratin 17provided by HGNC
    Primary source
    HGNC:HGNC:6427
    See related
    Ensembl:ENSG00000128422 MIM:148069; AllianceGenome:HGNC:6427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PC; K17; PC2; 39.1; CK-17; PCHC1
    Summary
    This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
    Expression
    Biased expression in urinary bladder (RPKM 147.9), skin (RPKM 53.6) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41619442..41624575, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42474895..42480028, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39775694..39780827, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39770050-39770598 Neighboring gene keratin 16 Neighboring gene keratin 42, pseudogene Neighboring gene uncharacterized LOC124904004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39803627-39804502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39809802-39810500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39810501-39811197

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of keratin 17 (KRT17) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hair follicle morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hair follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 17
    Names
    cytokeratin-17
    keratin 17, type I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008625.1 RefSeqGene

      Range
      5056..10189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1345

    mRNA and Protein(s)

    1. NM_000422.3NP_000413.1  keratin, type I cytoskeletal 17

      See identical proteins and their annotated locations for NP_000413.1

      Status: REVIEWED

      Source sequence(s)
      BC011901, BP226061
      Consensus CDS
      CCDS11402.1
      UniProtKB/Swiss-Prot
      A5Z1M9, A5Z1N0, A5Z1N1, A5Z1N2, A6NDV6, A6NKQ2, Q04695, Q6IP98, Q8N1P6
      Related
      ENSP00000308452.8, ENST00000311208.13
      Conserved Domains (1) summary
      pfam00038
      Location:84394
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41619442..41624575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42474895..42480028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)