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    HOXA13 homeobox A13 [ Homo sapiens (human) ]

    Gene ID: 3209, updated on 5-May-2024

    Summary

    Official Symbol
    HOXA13provided by HGNC
    Official Full Name
    homeobox A13provided by HGNC
    Primary source
    HGNC:HGNC:5102
    See related
    Ensembl:ENSG00000106031 MIM:142959; AllianceGenome:HGNC:5102
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX1; HOX1J
    Summary
    In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 14.7), placenta (RPKM 10.9) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    7p15.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (27194364..27200091, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (27330371..27336079, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27233983..27239710, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27222450-27223332 Neighboring gene NUP98-HOXA11 recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27223333-27224214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27225097-27225978 Neighboring gene homeobox A11 Neighboring gene HOXA11 antisense RNA Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27231749-27232306 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27232307-27232864 Neighboring gene NUP98-HOXA13 recombination region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27242057-27242581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244076-27244800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27244801-27245523 Neighboring gene HOXA distal transcript antisense RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27249966-27250466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27250467-27250967 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27252523-27253272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27253273-27254021 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27259729-27260290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27264497-27265180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27282039-27282916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:27284838-27285446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:27285447-27286056 Neighboring gene EVX1 antisense RNA Neighboring gene even-skipped homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with HOXA13 promoter to upregulate HOXA13 expression in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in artery morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in prostate gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic hindgut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner ear development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesenchymal cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mesenchymal cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in tissue homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular septum development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    homeobox protein Hox-A13
    Names
    homeo box 1J
    homeo box A13
    homeobox protein HOXA13
    homeobox protein Hox-1J
    transcription factor HOXA13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008181.2 RefSeqGene

      Range
      5016..10743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1349

    mRNA and Protein(s)

    1. NM_000522.5NP_000513.2  homeobox protein Hox-A13

      See identical proteins and their annotated locations for NP_000513.2

      Status: REVIEWED

      Source sequence(s)
      AC004080, BC075791
      Consensus CDS
      CCDS5412.1
      UniProtKB/Swiss-Prot
      A4D188, O43371, P31271
      UniProtKB/TrEMBL
      Q6DI00
      Related
      ENSP00000497112.1, ENST00000649031.1
      Conserved Domains (2) summary
      pfam00046
      Location:325379
      Homeobox; Homeobox domain
      pfam12284
      Location:85222
      HoxA13_N; Hox protein A13 N terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      27194364..27200091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      27330371..27336079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)