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    SMC3 structural maintenance of chromosomes 3 [ Homo sapiens (human) ]

    Gene ID: 9126, updated on 5-May-2024

    Summary

    Official Symbol
    SMC3provided by HGNC
    Official Full Name
    structural maintenance of chromosomes 3provided by HGNC
    Primary source
    HGNC:HGNC:2468
    See related
    Ensembl:ENSG00000108055 MIM:606062; AllianceGenome:HGNC:2468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAM; BMH; HCAP; CDLS3; CSPG6; SMC3L1
    Summary
    This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 37.2), bone marrow (RPKM 22.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SMC3 in Genome Data Viewer
    Location:
    10q25.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (110567695..110606048)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (111451468..111489803)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112327453..112365806)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:112313217-112313794 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:112313795-112314372 Neighboring gene uncharacterized LOC105378483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:112325756-112326458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2820 Neighboring gene ribosomal protein L7 pseudogene 35 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:112371015-112371952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4040 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:112396871-112397422 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:112400903-112401440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:112403057-112403601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:112410991-112411492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:112411493-112411992 Neighboring gene Sharpr-MPRA regulatory region 1411 Neighboring gene RNA binding motif protein 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4041 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:112444328-112444859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:112458065-112458564 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:112461376-112461982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:112468962-112469513 Neighboring gene uncharacterized LOC124902498 Neighboring gene RN7SK pseudogene 288

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with SMC3 in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed
    Vpr vpr HIV-1 Vpr decreases the amount of Smc1 and Smc3 proteins in the chromatin PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mediator complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of meiotic sister chromatid cohesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in establishment of mitotic sister chromatid cohesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
     
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sister chromatid cohesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome TAS
    Traceable Author Statement
    more info
     
    located_in chromosome, centromeric region TAS
    Traceable Author Statement
    more info
     
    part_of cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cohesin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in lateral element IEA
    Inferred from Electronic Annotation
    more info
     
    part_of meiotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic cohesin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of mitotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mitotic cohesin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of mitotic cohesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    structural maintenance of chromosomes protein 3
    Names
    SMC protein 3
    basement membrane-associated chondroitin proteoglycan
    chondroitin sulfate proteoglycan 6 (bamacan)
    chromosome-associated polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012217.1 RefSeqGene

      Range
      5001..41944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_774

    mRNA and Protein(s)

    1. NM_005445.4NP_005436.1  structural maintenance of chromosomes protein 3

      See identical proteins and their annotated locations for NP_005436.1

      Status: REVIEWED

      Source sequence(s)
      AF020043, AL359260, CA439554
      Consensus CDS
      CCDS31285.1
      UniProtKB/Swiss-Prot
      A8K156, O60464, Q5T482, Q9UQE7
      UniProtKB/TrEMBL
      Q86VX4
      Related
      ENSP00000354720.5, ENST00000361804.5
      Conserved Domains (1) summary
      COG1196
      Location:11194
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      110567695..110606048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      111451468..111489803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)