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    ZFYVE26 zinc finger FYVE-type containing 26 [ Homo sapiens (human) ]

    Gene ID: 23503, updated on 3-Apr-2024

    Summary

    Official Symbol
    ZFYVE26provided by HGNC
    Official Full Name
    zinc finger FYVE-type containing 26provided by HGNC
    Primary source
    HGNC:HGNC:20761
    See related
    Ensembl:ENSG00000072121 MIM:612012; AllianceGenome:HGNC:20761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPG15; FYVE-CENT
    Summary
    This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in skin (RPKM 3.6), spleen (RPKM 3.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    14q24.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (67728892..67816590, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (61936011..62023694, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68213239..68283307, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68195910-68196540 Neighboring gene RNA, 7SL, cytoplasmic 369, pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8587 Neighboring gene Sharpr-MPRA regulatory region 13811 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:68286883-68287644 Neighboring gene RNA, 7SL, cytoplasmic 213, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8588 Neighboring gene ribosomal protein L21 pseudogene 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68335343-68335842 Neighboring gene retinol dehydrogenase 12 Neighboring gene MPRA-validated peak2182 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:68395137-68396136 Neighboring gene RAD51 paralog B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:68552975-68553525 Neighboring gene centrosomal protein 170kDa pseudogene Neighboring gene uncharacterized LOC105370546 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:68604367-68605351 Neighboring gene RNA, 7SL, cytoplasmic 706, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hereditary spastic paraplegia 15
    MedGen: C1849128 OMIM: 270700 GeneReviews: Spastic Paraplegia 15
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0321, DKFZp781H1112, DKFZp686F19106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger FYVE domain-containing protein 26
    Names
    FYVE domain-containing centrosomal protein
    spastizin
    zinc finger, FYVE domain containing 26

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011836.2 RefSeqGene

      Range
      5000..75068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_015346.4NP_056161.2  zinc finger FYVE domain-containing protein 26

      See identical proteins and their annotated locations for NP_056161.2

      Status: REVIEWED

      Source sequence(s)
      AL049779, AL121595
      Consensus CDS
      CCDS9788.1
      UniProtKB/Swiss-Prot
      B1B5Y3, B4E2U3, O15035, Q68DK2, Q68DT9, Q6AW90, Q6ZR50, Q7Z3A4, Q7Z3I1, Q8N4W7, Q96H43
      UniProtKB/TrEMBL
      A0A7I2YQU3
      Related
      ENSP00000251119.5, ENST00000347230.9
      Conserved Domains (1) summary
      cd15724
      Location:18091869
      FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      67728892..67816590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431173.1XP_047287129.1  zinc finger FYVE domain-containing protein 26 isoform X1

      Related
      ENSP00000450603.1, ENST00000555452.1
    2. XM_047431175.1XP_047287131.1  zinc finger FYVE domain-containing protein 26 isoform X3

    3. XM_047431174.1XP_047287130.1  zinc finger FYVE domain-containing protein 26 isoform X2

    4. XM_011536609.3XP_011534911.1  zinc finger FYVE domain-containing protein 26 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      61936011..62023694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375728.1XP_054231703.1  zinc finger FYVE domain-containing protein 26 isoform X1

    2. XM_054375730.1XP_054231705.1  zinc finger FYVE domain-containing protein 26 isoform X3

    3. XM_054375729.1XP_054231704.1  zinc finger FYVE domain-containing protein 26 isoform X2

    4. XM_054375731.1XP_054231706.1  zinc finger FYVE domain-containing protein 26 isoform X4