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    SLC2A10 solute carrier family 2 member 10 [ Homo sapiens (human) ]

    Gene ID: 81031, updated on 3-Apr-2024

    Summary

    Official Symbol
    SLC2A10provided by HGNC
    Official Full Name
    solute carrier family 2 member 10provided by HGNC
    Primary source
    HGNC:HGNC:13444
    See related
    Ensembl:ENSG00000197496 MIM:606145; AllianceGenome:HGNC:13444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATS; ATORS; GLUT10
    Summary
    This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]
    Expression
    Broad expression in prostate (RPKM 8.3), thyroid (RPKM 6.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC2A10 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46708320..46736347)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (48444561..48472618)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45338288..45364986)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:45197011-45197512 Neighboring gene solute carrier family 13 member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45211603-45212425 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr20:45212426-45213247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17977 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:45250755-45251328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45259736-45260484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45260485-45261231 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:45302100-45302256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45303169-45303683 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45311939-45312450 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17979 Neighboring gene TP53RK divergent transcript Neighboring gene TP53 regulating kinase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:45331499-45332271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354240-45354740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:45354741-45355241 Neighboring gene uncharacterized LOC124904918 Neighboring gene uncharacterized LOC124904919

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126706

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    acts_upstream_of_or_within artery development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circulatory system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dehydroascorbic acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal joint development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in galactose transmembrane transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glucose import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glucose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucose transmembrane transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
     
    acts_upstream_of_or_within negative regulation of connective tissue growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 10
    Names
    GLUT-10
    facilitative glucose transporter GLUT10
    glucose transporter type 10
    solute carrier family 2 (facilitated glucose transporter), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016284.1 RefSeqGene

      Range
      5010..31708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_030777.4NP_110404.1  solute carrier family 2, facilitated glucose transporter member 10

      See identical proteins and their annotated locations for NP_110404.1

      Status: REVIEWED

      Source sequence(s)
      AF248053, AF321240
      Consensus CDS
      CCDS13402.1
      UniProtKB/Swiss-Prot
      A8K4J6, O95528, Q3MIX5, Q9H4I6
      UniProtKB/TrEMBL
      B2RCT7, B3KP22
      Related
      ENSP00000352216.2, ENST00000359271.4
      Conserved Domains (1) summary
      cl26863
      Location:11512
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      46708320..46736347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529062.3XP_011527364.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

      UniProtKB/TrEMBL
      B2RCT7
      Conserved Domains (2) summary
      cd06174
      Location:35351
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG0477
      Location:37344
      ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
    2. XM_011529060.3XP_011527362.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

      See identical proteins and their annotated locations for XP_011527362.1

      UniProtKB/TrEMBL
      B2RCT7, B3KP22
      Conserved Domains (2) summary
      cd06174
      Location:35518
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:32533
      Sugar_tr; Sugar (and other) transporter
    3. XM_011529065.3XP_011527367.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X8

      UniProtKB/TrEMBL
      B2RCT7
      Conserved Domains (2) summary
      cd06174
      Location:35351
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:32493
      Sugar_tr; Sugar (and other) transporter
    4. XM_047440528.1XP_047296484.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

    5. XM_011529063.3XP_011527365.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X5

      UniProtKB/TrEMBL
      B2RCT7
      Conserved Domains (2) summary
      cd06174
      Location:35351
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:32500
      Sugar_tr; Sugar (and other) transporter
    6. XM_011529064.3XP_011527366.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

      Conserved Domains (2) summary
      cd06174
      Location:35351
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      COG0477
      Location:37344
      ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]
    7. XM_011529061.3XP_011527363.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

      UniProtKB/TrEMBL
      B2RCT7, B3KP22
      Conserved Domains (2) summary
      cd06174
      Location:17500
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:14515
      Sugar_tr; Sugar (and other) transporter
    8. XM_047440529.1XP_047296485.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

    9. XM_017028087.3XP_016883576.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X9

      UniProtKB/TrEMBL
      B2RCT7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      48444561..48472618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324094.1XP_054180069.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X8

    2. XM_054324087.1XP_054180062.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X1

    3. XM_054324090.1XP_054180065.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X4

    4. XM_054324089.1XP_054180064.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X3

    5. XM_054324091.1XP_054180066.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X10

    6. XM_054324093.1XP_054180068.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X7

    7. XM_054324088.1XP_054180063.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X2

    8. XM_054324092.1XP_054180067.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X6

    9. XM_054324095.1XP_054180070.1  solute carrier family 2, facilitated glucose transporter member 10 isoform X9