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    KRT16 keratin 16 [ Homo sapiens (human) ]

    Gene ID: 3868, updated on 7-Apr-2024

    Summary

    Official Symbol
    KRT16provided by HGNC
    Official Full Name
    keratin 16provided by HGNC
    Primary source
    HGNC:HGNC:6423
    See related
    Ensembl:ENSG00000186832 MIM:148067; AllianceGenome:HGNC:6423
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 209.9) and esophagus (RPKM 198.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KRT16 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41609778..41612767, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42465231..42468220, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39766030..39769019, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39739983-39740483 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39741549-39742050 Neighboring gene keratin 14 Neighboring gene uncharacterized LOC124904003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39770050-39770598 Neighboring gene keratin 17 Neighboring gene keratin 42, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hair cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in keratinocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in morphogenesis of an epithelium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 16
    Names
    cytokeratin 16
    focal non-epidermolytic palmoplantar keratoderma
    keratin 16, type I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008301.1 RefSeqGene

      Range
      5061..8050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005557.4NP_005548.2  keratin, type I cytoskeletal 16

      See identical proteins and their annotated locations for NP_005548.2

      Status: REVIEWED

      Source sequence(s)
      AK290853, BC039169, DC394235
      Consensus CDS
      CCDS11401.1
      UniProtKB/Swiss-Prot
      A8K488, P08779, P30654, Q16402, Q9UBG8
      Related
      ENSP00000301653.3, ENST00000301653.9
      Conserved Domains (2) summary
      pfam00038
      Location:116427
      Filament; Intermediate filament protein
      cl14876
      Location:239327
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41609778..41612767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      42465231..42468220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)