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    RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 5894, updated on 13-May-2024

    Summary

    Official Symbol
    RAF1provided by HGNC
    Official Full Name
    Raf-1 proto-oncogene, serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:9829
    See related
    Ensembl:ENSG00000132155 MIM:164760; AllianceGenome:HGNC:9829
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS5; CRAF; Raf-1; c-Raf; CMD1NN
    Summary
    This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 34.4), heart (RPKM 32.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAF1 in Genome Data Viewer
    Location:
    3p25.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12583601..12664117, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12582405..12665632, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12625100..12705616, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12558643-12559143 Neighboring gene RNA, U6 small nuclear 377, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14065 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12598813-12599336 Neighboring gene MKRN2 opposite strand Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19446 Neighboring gene makorin ring finger protein 2 Neighboring gene MPRA-validated peak4543 silencer Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:12684584-12684794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12698025-12698668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12704698-12705308 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12705309-12705920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12711892-12712473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12712474-12713054 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12715375-12716244 Neighboring gene cysteine rich protein 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12735645-12736146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12779747-12780569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14068 Neighboring gene transmembrane protein 40 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19453 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12800761-12801346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14069

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Dilated cardiomyopathy 1NN
    MedGen: C4014656 OMIM: 615916 GeneReviews: Not available
    Compare labs
    LEOPARD syndrome 2 Compare labs
    Noonan syndrome 5
    MedGen: C1969057 OMIM: 611553 GeneReviews: Noonan Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-09-13)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-09-13)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced release of IL-10 depends on the activation of Raf-1 along with NF-kappaB p65 in immature dentritic cells PubMed
    env DC-SIGN-induced signaling by HIV-1 is essential for Raf-1-mediated phosphorylation of p65 NFkappaB at Ser276, which recruits pTEF-b to HIV-1 LTR to phosphorylate RNAPII at Ser2 PubMed
    env Interaction of gp120 with DC-SIGN activates Raf-1 and phosphorylates Raf-1 at positions Ser338, Tyr340, and Tyr341 PubMed
    env Binding of HIV-1 gp120 to CD4 molecules results in the association of Lck and Raf-1, which is abolished by preincubation of the virus with soluble CD4 PubMed
    Nef nef A conserved acidic sequence motif in HIV-1 Nef at positions 174-179 binds to c-Raf1; the interaction of Nef with c-Raf1 leads to a downstream transduction of cell signaling through the c-Raf1-MAP kinase pathway in vivo PubMed
    Tat tat HIV-1 Tat activates PRKCQ (PKC-theta) kinase activity, which leads to RELA (NFkB), NRAS, RAF1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAPK3 (ERK1), and MAPK1 (ERK2) activation, in Jurkat T cells that stably express Tat PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERBB2-ERBB3 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Schwann cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in death-inducing signaling complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in face development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intermediate filament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotrophin TRK receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell motility TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to muscle stretch IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type B pancreatic cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in type II interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in pseudopodium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    Names
    C-Raf proto-oncogene, serine/threonine kinase
    Oncogene RAF1
    proto-oncogene c-RAF
    raf proto-oncogene serine/threonine protein kinase
    v-raf-1 murine leukemia viral oncogene homolog 1
    v-raf-1 murine leukemia viral oncogene-like protein 1
    NP_001341618.1
    NP_001341619.1
    NP_001341620.1
    NP_001341621.1
    NP_001341622.1
    NP_001341623.1
    NP_001341624.1
    NP_002871.1
    XP_011532276.1
    XP_016862455.1
    XP_047304605.1
    XP_047304606.1
    XP_047304607.1
    XP_054203389.1
    XP_054203390.1
    XP_054203391.1
    XP_054203392.1
    XP_054203393.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007467.1 RefSeqGene

      Range
      4979..85579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_413

    mRNA and Protein(s)

    1. NM_001354689.3NP_001341618.1  RAF proto-oncogene serine/threonine-protein kinase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC018500, AC026170
      Consensus CDS
      CCDS87047.1
      UniProtKB/TrEMBL
      A0A0S2Z559, A0A8I5KSV6
      Related
      ENSP00000401888.2, ENST00000442415.7
      Conserved Domains (3) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139187
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001354690.3NP_001341619.1  RAF proto-oncogene serine/threonine-protein kinase isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC018500, AC026170
      Consensus CDS
      CCDS2612.1
      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, A0A8I5KSV6, L7RRS6
      Related
      ENSP00000508763.1, ENST00000691899.1
      Conserved Domains (3) summary
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    3. NM_001354691.3NP_001341620.1  RAF proto-oncogene serine/threonine-protein kinase isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variant 5, encodes isoform c.
      Source sequence(s)
      AC018500, AC026170
      UniProtKB/TrEMBL
      A0A8I5KSB0, B4E0X2
      Conserved Domains (2) summary
      cd14149
      Location:255537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. NM_001354692.3NP_001341621.1  RAF proto-oncogene serine/threonine-protein kinase isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 4, encodes isoform c.
      Source sequence(s)
      AC018500, AC026170
      UniProtKB/TrEMBL
      A0A8I5KSB0, B4E0X2
      Conserved Domains (2) summary
      cd14149
      Location:255537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    5. NM_001354693.3NP_001341622.1  RAF proto-oncogene serine/threonine-protein kinase isoform d

      Status: REVIEWED

      Source sequence(s)
      AC018500, AC026170
      Consensus CDS
      CCDS93217.1
      UniProtKB/TrEMBL
      A0A0S2Z4L5, A0A8I5KQV4, A0A8I5KTA5
      Related
      ENSP00000509612.1, ENST00000688543.1
      Conserved Domains (3) summary
      cd14149
      Location:303585
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    6. NM_001354694.3NP_001341623.1  RAF proto-oncogene serine/threonine-protein kinase isoform e

      Status: REVIEWED

      Source sequence(s)
      AC018500, AC026170
      UniProtKB/TrEMBL
      A0A8I5KSB0
      Conserved Domains (2) summary
      cd14149
      Location:275557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58106
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    7. NM_001354695.3NP_001341624.1  RAF proto-oncogene serine/threonine-protein kinase isoform f

      Status: REVIEWED

      Source sequence(s)
      AC018500, AC026170
      UniProtKB/TrEMBL
      A0A8I5KSB0
      Conserved Domains (2) summary
      cd14149
      Location:222504
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    8. NM_002880.4NP_002871.1  RAF proto-oncogene serine/threonine-protein kinase isoform b

      See identical proteins and their annotated locations for NP_002871.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
      Source sequence(s)
      BC018119, BU683389, DC342671
      Consensus CDS
      CCDS2612.1
      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, A0A8I5KSV6, L7RRS6
      Related
      ENSP00000251849.4, ENST00000251849.9
      Conserved Domains (3) summary
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    RNA

    1. NR_148940.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018500, AC026170
      Related
      ENST00000685738.1
    2. NR_148941.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018500, AC026170
      Related
      ENST00000689914.1
    3. NR_148942.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018500, AC026170
      Related
      ENST00000691724.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      12583601..12664117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448651.1XP_047304607.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z4L5
      Related
      ENSP00000509669.1, ENST00000692093.1
    2. XM_011533974.3XP_011532276.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_011532276.1

      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, A0A8I5KSV6, L7RRS6
      Conserved Domains (3) summary
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    3. XM_047448649.1XP_047304605.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, L7RRS6
      Related
      ENSP00000509968.1, ENST00000685653.1
    4. XM_047448650.1XP_047304606.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, L7RRS6
    5. XM_017006966.1XP_016862455.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z4L5, A0A8I5KQV4, A0A8I5KTA5
      Conserved Domains (3) summary
      cd14149
      Location:303585
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      12582405..12665632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347417.1XP_054203392.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z4L5
    2. XM_054347414.1XP_054203389.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, L7RRS6
    3. XM_054347415.1XP_054203390.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, L7RRS6
    4. XM_054347416.1XP_054203391.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      B0LPH8, B2R5N3, P04049, Q15278, Q9UC20
      UniProtKB/TrEMBL
      A0A024R2G5, L7RRS6
    5. XM_054347418.1XP_054203393.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z4L5