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    CILK1 ciliogenesis associated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 22858, updated on 13-Jun-2024

    Summary

    Official Symbol
    CILK1provided by HGNC
    Official Full Name
    ciliogenesis associated kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:21219
    See related
    Ensembl:ENSG00000112144 MIM:612325; AllianceGenome:HGNC:21219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ECO; ICK; MRK; LCK2; hICK; EJM10
    Summary
    Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 9.9), placenta (RPKM 5.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CILK1 in Genome Data Viewer
    Location:
    6p12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (53001303..53061824, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52840881..52901428, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52866101..52926622, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92160 Neighboring gene glutathione S-transferase alpha 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:52860003-52860234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17287 Neighboring gene RNA component of 7SK nuclear ribonucleoprotein Neighboring gene uncharacterized LOC128092246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:52908870-52909424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17288 Neighboring gene uncharacterized LOC128031835 Neighboring gene F-box protein 9 Neighboring gene RNA, 7SL, cytoplasmic 244, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0936, MGC46090

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intraciliary anterograde transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intraciliary retrograde transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intraciliary transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary base ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary tip IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase ICK
    Names
    MAK-related kinase
    iciliogenesis associated kinase 1
    intestinal cell (MAK-like) kinase
    intestinal cell kinase
    laryngeal cancer kinase 2
    serine/threonine protein kinase
    NP_001362326.1
    NP_001362327.1
    NP_001362328.1
    NP_001362329.1
    NP_001362330.1
    NP_001362331.1
    NP_055735.1
    NP_057597.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012159.2 RefSeqGene

      Range
      4979..65500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375397.1NP_001362326.1  serine/threonine-protein kinase ICK isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS93933.1
      UniProtKB/TrEMBL
      A0A7I2PIU1, B3KQG4
      Related
      ENSP00000263043.8, ENST00000350082.10
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    2. NM_001375398.1NP_001362327.1  serine/threonine-protein kinase ICK isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    3. NM_001375399.1NP_001362328.1  serine/threonine-protein kinase ICK isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    4. NM_001375400.1NP_001362329.1  serine/threonine-protein kinase ICK isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    5. NM_001375401.1NP_001362330.1  serine/threonine-protein kinase ICK isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    6. NM_001375402.1NP_001362331.1  serine/threonine-protein kinase ICK isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    7. NM_014920.5NP_055735.1  serine/threonine-protein kinase ICK isoform 1

      See identical proteins and their annotated locations for NP_055735.1

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Related
      ENSP00000501692.1, ENST00000676107.1
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases
    8. NM_016513.5NP_057597.2  serine/threonine-protein kinase ICK isoform 1

      See identical proteins and their annotated locations for NP_057597.2

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581
      Consensus CDS
      CCDS4949.1
      UniProtKB/Swiss-Prot
      A7MD41, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3, Q9UPZ9
      UniProtKB/TrEMBL
      B3KQG4
      Related
      ENSP00000349458.3, ENST00000356971.3
      Conserved Domains (1) summary
      cd07830
      Location:4284
      STKc_MAK_like; Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases

    RNA

    1. NR_164684.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031178, AL162581

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      53001303..53061824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      52840881..52901428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173041.1: Suppressed sequence

      Description
      NM_173041.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.