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    ANG angiogenin [ Homo sapiens (human) ]

    Gene ID: 283, updated on 11-Apr-2024

    Summary

    Official Symbol
    ANGprovided by HGNC
    Official Full Name
    angiogeninprovided by HGNC
    Primary source
    HGNC:HGNC:483
    See related
    Ensembl:ENSG00000214274 MIM:105850; AllianceGenome:HGNC:483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALS9; RAA1; HEL168; RNASE4; RNASE5
    Summary
    The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]
    Expression
    Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    14q11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20684177..20694186)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14881287..14891295)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21152336..21162345)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5573 Neighboring gene tRNA-Tyr (anticodon GTA) 5-5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8093 Neighboring gene tRNA-Pro (anticodon TGG) 3-2 Neighboring gene ribonuclease A family member 4 Neighboring gene EGFR interacting lncRNA Neighboring gene ReSE screen-validated silencer GRCh37_chr14:21167810-21167975 Neighboring gene uncharacterized LOC124903282 Neighboring gene RAN binding protein 20 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG (Angiogenin), ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1, ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 compared to healthy donors PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC22466, MGC71966

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IC
    Inferred by Curator
    more info
    PubMed 
    enables RNA endonuclease activity TAS
    Traceable Author Statement
    more info
     
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endonuclease activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables rRNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of phospholipase A2 activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of phospholipase C activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of protein kinase B activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell communication NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diacylglycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homeostatic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oocyte maturation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ovarian follicle development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in placenta development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to hypoxia NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in tRNA decay TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    part_of angiogenin-PRI complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of angiogenin-PRI complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    angiogenin
    Names
    RNase 5
    angiogenin, ribonuclease, RNase A family, 5
    epididymis luminal protein 168
    ribonuclease 5
    ribonuclease A A1
    ribonuclease A family member 5
    NP_001091046.1
    NP_001136.1
    NP_001372200.1
    NP_001372201.1
    NP_001372202.1
    NP_001372203.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008717.2 RefSeqGene

      Range
      5001..15010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_653

    mRNA and Protein(s)

    1. NM_001097577.3NP_001091046.1  angiogenin precursor

      See identical proteins and their annotated locations for NP_001091046.1

      Status: REVIEWED

      Source sequence(s)
      AL163636
      Consensus CDS
      CCDS9554.1
      UniProtKB/Swiss-Prot
      P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7
      UniProtKB/TrEMBL
      W0UV28
      Related
      ENSP00000381077.4, ENST00000397990.5
      Conserved Domains (1) summary
      smart00092
      Location:26143
      RNAse_Pc; Pancreatic ribonuclease
    2. NM_001145.4NP_001136.1  angiogenin precursor

      See identical proteins and their annotated locations for NP_001136.1

      Status: REVIEWED

      Source sequence(s)
      AL163636
      Consensus CDS
      CCDS9554.1
      UniProtKB/Swiss-Prot
      P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7
      UniProtKB/TrEMBL
      W0UV28
      Related
      ENSP00000336762.6, ENST00000336811.10
      Conserved Domains (1) summary
      smart00092
      Location:26143
      RNAse_Pc; Pancreatic ribonuclease
    3. NM_001385271.1NP_001372200.1  angiogenin precursor

      Status: REVIEWED

      Source sequence(s)
      AL163636
      Consensus CDS
      CCDS9554.1
      UniProtKB/Swiss-Prot
      P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7
      UniProtKB/TrEMBL
      W0UV28
      Conserved Domains (1) summary
      smart00092
      Location:26143
      RNAse_Pc; Pancreatic ribonuclease
    4. NM_001385272.1NP_001372201.1  angiogenin precursor

      Status: REVIEWED

      Source sequence(s)
      AL163636
      Consensus CDS
      CCDS9554.1
      UniProtKB/Swiss-Prot
      P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7
      UniProtKB/TrEMBL
      W0UV28
      Conserved Domains (1) summary
      smart00092
      Location:26143
      RNAse_Pc; Pancreatic ribonuclease
    5. NM_001385273.1NP_001372202.1  angiogenin precursor

      Status: REVIEWED

      Source sequence(s)
      AL163636
      Consensus CDS
      CCDS9554.1
      UniProtKB/Swiss-Prot
      P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7
      UniProtKB/TrEMBL
      W0UV28
      Conserved Domains (1) summary
      smart00092
      Location:26143
      RNAse_Pc; Pancreatic ribonuclease
    6. NM_001385274.1NP_001372203.1  angiogenin precursor

      Status: REVIEWED

      Source sequence(s)
      AL163636
      Consensus CDS
      CCDS9554.1
      UniProtKB/Swiss-Prot
      P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7
      UniProtKB/TrEMBL
      W0UV28
      Conserved Domains (1) summary
      smart00092
      Location:26143
      RNAse_Pc; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      20684177..20694186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14881287..14891295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)