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    RPL11 ribosomal protein L11 [ Homo sapiens (human) ]

    Gene ID: 6135, updated on 17-Jun-2024

    Summary

    Official Symbol
    RPL11provided by HGNC
    Official Full Name
    ribosomal protein L11provided by HGNC
    Primary source
    HGNC:HGNC:10301
    See related
    Ensembl:ENSG00000142676 MIM:604175; AllianceGenome:HGNC:10301
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L11; uL5; DBA7; GIG34
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 1447.2), bone marrow (RPKM 910.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RPL11 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23691779..23696835)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23526679..23531735)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24018269..24023325)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myelodysplastic syndrome 2 translocation associated Neighboring gene ATAC-STARR-seq lymphoblastoid active region 373 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 48 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24024040-24024661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 420 Neighboring gene elongin A Neighboring gene Sharpr-MPRA regulatory region 2978 Neighboring gene ELOA antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24103632-24104584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 422 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:24105838-24107037 Neighboring gene PITH domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with RPL11 as demonstrated by proximity dependent biotinylation proteomics PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of ribosomal protein L11 (RPL11) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 5S rRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables ubiquitin ligase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein neddylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL5
    Names
    60S ribosomal protein L11
    CLL-associated antigen KW-12
    cell growth-inhibiting protein 34

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011741.2 RefSeqGene

      Range
      5028..10057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1140

    mRNA and Protein(s)

    1. NM_000975.5NP_000966.2  large ribosomal subunit protein uL5 isoform 1

      See identical proteins and their annotated locations for NP_000966.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA748897, AL451000, BU954396, BX118515, CA335141
      Consensus CDS
      CCDS238.1
      UniProtKB/Swiss-Prot
      P25121, P39026, P62913, Q8TDH2, Q9Y674
      UniProtKB/TrEMBL
      Q08ES8, Q5VVD0
      Related
      ENSP00000496250.1, ENST00000643754.2
      Conserved Domains (1) summary
      PTZ00156
      Location:5175
      PTZ00156; 60S ribosomal protein L11; Provisional
    2. NM_001199802.1NP_001186731.1  large ribosomal subunit protein uL5 isoform 2

      See identical proteins and their annotated locations for NP_001186731.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks 3 nts at an alternate splice site, as compared to variant 1. The resulting isoform (2) lacks an internal aa in the N-terminal region, as compared to isoform 1.
      Source sequence(s)
      BC018970, BF240826, BU954396, CA335141
      Consensus CDS
      CCDS85940.1
      UniProtKB/TrEMBL
      Q08ES8
      Related
      ENSP00000363676.4, ENST00000374550.8
      Conserved Domains (1) summary
      PTZ00156
      Location:4174
      PTZ00156; 60S ribosomal protein L11; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23691779..23696835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23526679..23531735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)